Efficacy of zinc oxide nanoparticles in attenuating pancreatic damage in a rat model of streptozotocin-induced diabetes

被引：29
|
作者：
Wahba, Nashwa S. [1 ]
Shaban, Sahar F. [1 ]
Kattaia, Asmaa A. A. [1 ]
Kandeel, Sara A. [1 ]
机构：
[1] Zagazig Univ, Fac Med, Dept Histol & Cell Biol, Zagazig, Egypt
来源：
ULTRASTRUCTURAL PATHOLOGY | 2016年 / 40卷 / 06期
关键词：
Diabetes; histopathology; rat; pancreas; zinc oxide nanoparticles; OXIDATIVE STRESS; NITRIC-OXIDE; ANTIOXIDANT STATUS; STELLATE CELLS; LEAF EXTRACT; MECHANISM; APOPTOSIS; INHIBITION; CYTOKINES; FIBROSIS;
D O I：
10.1080/01913123.2016.1246499
中图分类号：
TH742 [显微镜];
学科分类号：
摘要：
Zinc oxide nanoparticles (ZnO NPs) therapy is a promising strategy for treatment of several diseases. We aimed to investigate the therapeutic potential of ZnO NPs in ameliorating the histopathological and functional alterations in the pancreas of a rat model of streptozotocin-induced diabetes. Rats were randomized into control, diabetic and ZnO NPs-treated diabetic groups. Biochemical assays of blood glucose and serum insulin were performed. Pancreas specimens were processed for light and electron microscope examinations. ZnO NPs effectively reversed diabetes-induced pancreatic injury, as evidenced by the structural and ultrastructural improvement and confirmed by biochemical normalization of blood glucose and serum insulin.
引用
收藏
页码：358 / 373
页数：16
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