Efficacy of zinc oxide nanoparticles in attenuating pancreatic damage in a rat model of streptozotocin-induced diabetes

被引：29

作者：

Wahba, Nashwa S. ^{[1
]}

Shaban, Sahar F. ^{[1
]}

Kattaia, Asmaa A. A. ^{[1
]}

Kandeel, Sara A. ^{[1
]}

机构：

[1] Zagazig Univ, Fac Med, Dept Histol & Cell Biol, Zagazig, Egypt

来源：

ULTRASTRUCTURAL PATHOLOGY | 2016年 / 40卷 / 06期

关键词：

Diabetes; histopathology; rat; pancreas; zinc oxide nanoparticles; OXIDATIVE STRESS; NITRIC-OXIDE; ANTIOXIDANT STATUS; STELLATE CELLS; LEAF EXTRACT; MECHANISM; APOPTOSIS; INHIBITION; CYTOKINES; FIBROSIS;

D O I：

10.1080/01913123.2016.1246499

中图分类号：

TH742 [显微镜];

学科分类号：

摘要：

Zinc oxide nanoparticles (ZnO NPs) therapy is a promising strategy for treatment of several diseases. We aimed to investigate the therapeutic potential of ZnO NPs in ameliorating the histopathological and functional alterations in the pancreas of a rat model of streptozotocin-induced diabetes. Rats were randomized into control, diabetic and ZnO NPs-treated diabetic groups. Biochemical assays of blood glucose and serum insulin were performed. Pancreas specimens were processed for light and electron microscope examinations. ZnO NPs effectively reversed diabetes-induced pancreatic injury, as evidenced by the structural and ultrastructural improvement and confirmed by biochemical normalization of blood glucose and serum insulin.

引用

页码：358 / 373

页数：16

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