3D Printing of Highly Stretchable and Tough Hydrogels into Complex, Cellularized Structures

被引：5

作者：

Hong, Sungmin ^{[1
]}

Sycks, Dalton ^{[1
]}

Chan, Hon Fai ^{[2
]}

Lin, Shaoting ^{[1
,3
]}

Lopez, Gabriel P. ^{[1
,2
]}

Guilak, Farshid ^{[1
,2
,4
]}

Leong, Kam W. ^{[2
,5
]}

Zhao, Xuanhe ^{[1
,3
,6
]}

机构：

[1] Duke Univ, Dept Mech Engn & Mat Sci, Durham, NC 27708 USA

[2] Duke Univ, Dept Biomed Engn, Durham, NC 27708 USA

[3] MIT, Dept Mech Engn, Cambridge, MA 02139 USA

[4] Duke Univ, Med Ctr, Dept Orthopaed Surg, Durham, NC 27710 USA

[5] Columbia Univ, Dept Biomed Engn, New York, NY 10027 USA

[6] MIT, Dept Civil & Environm Engn, Cambridge, MA 02139 USA

来源：

ADVANCED MATERIALS | 2015年 / 27卷 / 27期

基金：

美国国家科学基金会;

关键词：

3D printing; cellularized structure; tough hydrogel; poly (ethylene glycol)-alginate; nanoclay; FRACTURE-TOUGHNESS; NETWORK HYDROGELS; CROSS-LINKING; SCAFFOLDS; CARTILAGE; STRENGTH; TISSUES; DESIGN;

D O I：

10.1002/adma.201501099

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A 3D printable and highly stretchable tough hydrogel is developed by combining poly(ethylene glycol) and sodium alginate, which synergize to form a hydrogel tougher than natural cartilage. Encapsulated cells maintain high viability over a 7 d culture period and are highly deformed together with the hydrogel. By adding biocompatible nanoclay, the tough hydrogel is 3D printed in various shapes without requiring support material. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：4035 / 4040

页数：6

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