Do aminopyridinium-based ionic liquids promising to control Culex pipiens mosquitoes in the future?

In Al-Madinah Al-Munawwarah region, Kingdom of Saudi Arabia, Culex pipiens is considered one of the most common mosquitoes. Owing to their exceptional chemical, physical, biological, and eco-friendly properties, ionic liquids (ILs) have been recently considered promising compounds in managing a variety of organisms. Six aminopyridinium-based IL derivatives were assessed to follow their efficacy against adults of C. pipiens. Mosquitoes were treated with aminopyridinium-based IL derivatives either orally or by spraying. It was observed in the first three days of treatment that the accumulated mortality rates were generally higher in sprayed mosquitoes with IL derivatives than their accumulated mortality rates in orally treated mosquitoes with the same ILs. It was also observed that the accumulated mortalities of sprayed mosquitoes at 0.125 and 0.25 g/L were higher than those in mosquitoes orally treated with the same concentrations. The highest mortality rates were 64 and 80% for sprayed and orally treated mosquitoes, respectively. The mode of action of aminopyridinium-based IL derivatives was tracked, and it is demonstrated to be through the digestive route for orally treated mosquitoes. This is the first study to show the adulticidal effects of aminopyridinium-based ILs in controlling C. pipiens.