Reverse engineering models of cell cycle regulation

被引:0
|
作者
Csikasz-Nagy, Attila [1 ]
Novak, Bela [1 ]
Tyson, John J. [1 ]
机构
[1] Hungarian Acad Sci, Mat Struct & Modeling Res Grp, H-1521 Budapest, Hungary
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中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
From general considerations of the basic physiological properties of the cell division cycle, we deduce what the dynamical properties of the underlying molecular control system must be. Then, taking a few hints from the biochemistry of cyclin-dependent kinases (the master regulators of the eukaryotic cell cycle), we guess what molecular mechanisms must be operating to produce the desired dynamical properties of the control system.
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页码:88 / 97
页数:10
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