Reverse engineering models of cell cycle regulation

被引：0
|
作者：
Csikasz-Nagy, Attila [1 ]
Novak, Bela [1 ]
Tyson, John J. [1 ]
机构：
[1] Hungarian Acad Sci, Mat Struct & Modeling Res Grp, H-1521 Budapest, Hungary
来源：
CELLULAR OSCILLATORY MECHANISMS | 2008年 / 641卷
关键词：
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
From general considerations of the basic physiological properties of the cell division cycle, we deduce what the dynamical properties of the underlying molecular control system must be. Then, taking a few hints from the biochemistry of cyclin-dependent kinases (the master regulators of the eukaryotic cell cycle), we guess what molecular mechanisms must be operating to produce the desired dynamical properties of the control system.
引用
收藏
页码：88 / 97
页数：10
相关论文
共 50 条
  • [1] Mathematical models of cell cycle regulation
    Fuss, H
    Dubitzky, W
    Downes, CS
    Kurth, MJ
    [J]. BRIEFINGS IN BIOINFORMATICS, 2005, 6 (02) : 163 - 177
  • [2] Reverse engineering systems models of regulation: discovery, prediction and mechanisms
    Ashworth, Justin
    Wurtmann, Elisabeth J.
    Baliga, Nitin S.
    [J]. CURRENT OPINION IN BIOTECHNOLOGY, 2012, 23 (04) : 598 - 603
  • [3] Reverse Engineering Feature Models
    She, Steven
    Lotufo, Rafael
    Berger, Thorsten
    Wasowski, Andrzej
    Czarnecki, Krzysztof
    [J]. 2011 33RD INTERNATIONAL CONFERENCE ON SOFTWARE ENGINEERING (ICSE), 2011, : 461 - 470
  • [4] Reverse engineering of gene regulation models from multi-condition experiments
    Kennedy, Noel
    Mizeranschi, Alexandru
    Thompson, Paul
    Zheng, Huiru
    Dubitzky, Werner
    [J]. PROCEEDINGS OF THE 2013 IEEE SYMPOSIUM ON COMPUTATIONAL INTELLIGENCE IN BIOINFORMATICS AND COMPUTATIONAL BIOLOGY (CIBCB), 2013, : 112 - 119
  • [5] Genetic mouse models to investigate cell cycle regulation
    Weimin Li
    Shuhei Kotoshiba
    Philipp Kaldis
    [J]. Transgenic Research, 2009, 18 : 491 - 498
  • [6] Genetic mouse models to investigate cell cycle regulation
    Li, Weimin
    Kotoshiba, Shuhei
    Kaldis, Philipp
    [J]. TRANSGENIC RESEARCH, 2009, 18 (04) : 491 - 498
  • [7] Reverse engineering the cell
    Nicholas T. Ingolia
    Jonathan S. Weissman
    [J]. Nature, 2008, 454 : 1061 - 1062
  • [8] Reverse Engineering of Protein Secretion by Uncoupling of Cell Cycle Phases From Growth
    Buchetics, Markus
    Dragosits, Martin
    Maurer, Michael
    Rebnegger, Corinna
    Porro, Danilo
    Sauer, Michael
    Gasser, Brigitte
    Mattanovich, Diethard
    [J]. BIOTECHNOLOGY AND BIOENGINEERING, 2011, 108 (10) : 2403 - 2412
  • [9] Dynamical and topological robustness of the mammalian cell cycle network: A reverse engineering approach
    Ruz, Gonzalo A.
    Goles, Eric
    Montalva, Marco
    Fogel, Gary B.
    [J]. BIOSYSTEMS, 2014, 115 : 23 - 32
  • [10] Leveraging the Systems Engineering Life Cycle Process for Reverse Engineering
    Daily, Jeremy
    Eddy, Amy
    [J]. INCOSE International Symposium, 2022, 32 (01) : 903 - 917
12345