Naseseazine C, a new anti-plasmodial dimeric diketopiperazine from a marine sediment derived Streptomyces sp.

被引：30
|
作者：
Buedenbender, Larissa [1 ]
Grkovic, Tanja [2 ]
Duffy, Sandra [2 ]
Kurtboke, D. Ipek [3 ]
Avery, Vicky M. [2 ]
Carroll, Anthony R. [1 ,2 ]
机构：
[1] Griffith Univ, Griffith Sch Environm, Gold Coast Campus, Southport, Qld 4222, Australia
[2] Griffith Univ, Eskitis Inst Drug Discovery, Brisbane, Qld 4111, Australia
[3] Univ Sunshine Coast, Genecol Res Ctr, Fac Sci Hlth Educ & Engn, Maroochydore, Qld 4558, Australia
来源：
TETRAHEDRON LETTERS | 2016年 / 57卷 / 52期
基金：
澳大利亚研究理事会;
关键词：
Marine Streptomyces species; Naseseazines; Diketopiperazines; Anti-plasmodial;
D O I：
10.1016/j.tetlet.2016.11.071
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new dimeric diketopiperazine, naseseazine C, and the known naseseazines A and B were isolated from solid culture extracts of an Australian marine sediment derived Streptomyces species. Naseseazine C displayed a new C-6'/C-3 linkage between the two diketopiperazine subunits and showed moderate activity against the chloroquine-sensitive malaria parasite, Plasmodium falciparum (3D7 strain). (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5893 / 5895
页数：3
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