IL-33/ST2 axis in innate and acquired immunity to tumors

被引：57
|
作者：
Jovanovic, Ivan P. [1 ]
Pejnovic, Nada N. [1 ]
Radosavljevic, Gordana D. [1 ]
Arsenijevic, Nebojsa N. [1 ]
Lukic, Miodrag L. [1 ]
机构：
[1] Univ Kragujevac, Fac Med, Ctr Mol Med & Stem Cell Res, Kragulevac, Serbia
来源：
ONCOIMMUNOLOGY | 2012年 / 1卷 / 02期
关键词：
IL-33; ST2L; 4T1 mouse breast cancer; Th1/Th2; cells; cytotoxic response; NK cells; INFLAMMATION; TYPE-1;
D O I：
10.4161/onci.1.2.18131
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Interleukin-33, a ligand for ST2/T1, has an important role in allergy, autoimmunity and inflammation. The role of IL-33/ST2 axis in cancer is not elucidated. Using metastatic breast cancer model we provide evidence that lack of ST2 signaling led to reduced tumor growth and metastasis and enhanced anti-tumor immunity.
引用
收藏
页码：229 / 231
页数：3
相关论文
共 50 条
  • [1] Innate Immunity Modulation by the IL-33/ST2 System in Intestinal Mucosa
    Garcia-Miguel, Marina
    Julieta Gonzalez, M.
    Quera, Rodrigo
    Hermoso, Marcela A.
    BIOMED RESEARCH INTERNATIONAL, 2013, 2013
  • [2] IL-33/ST2 axis in autoimmune disease
    Shakerian, Leila
    Kolahdooz, Hanieh
    Garousi, Mitra
    Keyvani, Vahideh
    Kheder, Ramiar Kamal
    Faraj, Tola Abdulsattar
    Yazdanpanah, Esmaeil
    Esmaeili, Seyed-Alireza
    CYTOKINE, 2022, 158
  • [3] IL-33/ST2 Axis in Organ Fibrosis
    Kotsiou, Ourania S.
    Gourgoulianis, Konstantinos I.
    Zarogiannis, Sotirios G.
    FRONTIERS IN IMMUNOLOGY, 2018, 9
  • [4] IL-33/ST2 axis in inflammation and immunopathology
    Marija Milovanovic
    Vladislav Volarevic
    Gordana Radosavljevic
    Ivan Jovanovic
    Nada Pejnovic
    Nebojsa Arsenijevic
    Miodrag L. Lukic
    Immunologic Research, 2012, 52 : 89 - 99
  • [5] IL-33/ST2 axis in inflammation and immunopathology
    Milovanovic, Marija
    Volarevic, Vladislav
    Radosavljevic, Gordana
    Jovanovic, Ivan
    Pejnovic, Nada
    Arsenijevic, Nebojsa
    Lukic, Miodrag L.
    IMMUNOLOGIC RESEARCH, 2012, 52 (1-2) : 89 - 99
  • [6] The IL-33/ST2 Axis Is Not Required for the Profibrotic Effect of IL-33 in the Lungs
    Atamas, Sergei P.
    Lockatell, Virginia
    Todd, Nevins W.
    Luzina, Irina G.
    AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2024, 71 (04) : 499 - 501
  • [7] IL-33/ST2 Axis Plays a Protective Effect in Streptococcus pyogenes Infection through Strengthening of the Innate Immunity
    Kuo, Chih-Feng
    Chen, Wei-Yu
    Yu, Hai-Han
    Tsai, Yu-Hsuan
    Chang, Ya-Chu
    Chang, Chih-Peng
    Tsao, Nina
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (19)
  • [8] The IL-33/ST2 axis: Role in health and disease
    De la Fuente, Marjorie
    MacDonald, Thomas T.
    Hermoso, Marcela A.
    CYTOKINE & GROWTH FACTOR REVIEWS, 2015, 26 (06) : 615 - 623
  • [9] The role of IL-33/ST2 axis in Colorectal Cancer
    Mahmoud, A. M.
    O'Donnell, C. O. D.
    Carey, S. C.
    O'Riordain, M.
    Bennett, M. W. B.
    Brint, E. B.
    Houston, A. H.
    JOURNAL OF PATHOLOGY, 2015, 237 : S43 - S43
  • [10] Potential role of the IL-33/ST2 axis in celiac disease
    MA López-Casado
    P Lorite
    T Palomeque
    MI Torres
    Cellular & Molecular Immunology, 2017, 14 : 285 - 292
12345