Oxidative Stress Response Induced by Butachlor in Zebrafish Embryo/Larvae: The Protective Effect of Vitamin C

被引：15
|
作者：
Xiang, Qingqing [1 ]
Xu, Bofan [1 ]
Ding, Yilun [3 ]
Liu, Xiaoyi [1 ]
Zhou, Ying [1 ,2 ]
Ahmad, Farooq [4 ]
机构：
[1] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310032, Zhejiang, Peoples R China
[2] Zhejiang Univ Technol, Res Ctr Anal & Measurement, Hangzhou 310032, Zhejiang, Peoples R China
[3] Montverde Acad Shanghai, Shanghai 201702, Peoples R China
[4] Shanghai Jiao Tong Univ, Sch Mat Sci & Engn, State Key Lab Met Matrix Composites, 800 Dongchuan Rd, Shanghai, Peoples R China
来源：
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY | 2018年 / 100卷 / 02期
关键词：
Butachlor; Oxidative stress; Protective effect; Vitamin C; Zebrafish; HERBICIDE BUTACHLOR; ACUTE TOXICITY; HUMAN ERYTHROCYTES; DANIO-RERIO; IN-VITRO; WATER; CHLORPYRIFOS; EXPOSURE; ASSAY; GC;
D O I：
10.1007/s00128-017-2245-9
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
The widespread contamination and persistence of the herbicide butachlor in the environment resulted in the exposure of non-target organisms. The present study investigated the toxicity effect of butachlor (1-15 A mu mol/L) and the protective effect of vitamin C (VC) against butachlor-induced toxicity in zebrafish. It was found that butachlor significantly increased the mortality and malformation rates in a dose-dependent manner, which caused elevation in reactive oxygen species (ROS) and malondialdehyde (MDA) after 72 h exposure. Compared with butachlor treatment group, the protective effect of VC against butachlor-induced toxicity were observed after adding 40, 80 mg/L VC respectively. VC significantly decreased the mortality, malformation rates, ROS, MDA, and normalized antioxidant enzymes activities of zebrafish after 72 h exposure. The result shows VC has mitigative effect on butachlor-induced toxicity and it can be used as an effective antioxidant in aquaculture.
引用
收藏
页码：208 / 215
页数：8
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