3D-printed microneedle arrays for drug delivery

被引：28
|
作者：
Li, Rong [1 ,2 ]
Zhang, Li [1 ,2 ]
Jiang, Xuebing [1 ,2 ]
Li, Li [1 ,2 ]
Wu, Shanshan [3 ]
Yuan, Xin [1 ,2 ]
Cheng, Hao [1 ,2 ,4 ]
Jiang, Xian [5 ]
Gou, Maling [1 ,2 ]
机构：
[1] Sichuan Univ, State Key Lab Biotherapy, Chengdu 610041, Peoples R China
[2] Sichuan Univ, West China Hosp, Canc Ctr, Chengdu 610041, Peoples R China
[3] Sichuan Univ, West China Hosp, Dept Ophthalmol, Chengdu 610041, Peoples R China
[4] Huahang Microcreate Technol Co Ltd, Chengdu 610042, Peoples R China
[5] Sichuan Univ, West China Hosp, Dept Dermatol, Chengdu 610041, Peoples R China
来源：
JOURNAL OF CONTROLLED RELEASE | 2022年 / 350卷
关键词：
3D printing; Microneedle arrays; Drug delivery; Product development; 2-PHOTON POLYMERIZATION; TRANSDERMAL DELIVERY; SKIN MODELS; FABRICATION; TECHNOLOGIES; DEVICES; PATCH; TOOL;
D O I：
10.1016/j.jconrel.2022.08.022
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Microneedle arrays provide an efficient tool for transdermal drug delivery in a minimally invasive and painless manner, showing great potential applications in medicine. However, it remains challenging to fabricate the desired microneedle arrays, because of their micron-scale size and fine structure. Novel manufacturing technologies are very wanted for the development of microneedle arrays, which would solidly advance the clinical translation of microneedle arrays. 3D printing technology is a powerful manufacturing technology with superiority in fabricating personalized and complex structures. Currently, 3D printing technology has been employed to fabricate microneedle arrays, which could push more microneedle arrays into clinic and inspire the development of future microneedle arrays. This work reviews the art of 3D printing microneedle arrays, the benefits of fabricating microneedle arrays with 3D printing, and the considerations for clinical translation of 3D-printed microneedle arrays. This work provides an overview of the current 3D-printed microneedle arrays in drug delivery.
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页码：933 / 948
页数：16
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