Henrin A: A New Anti-HIV Ent-Kaurane Diterpene from Pteris henryi

被引：16

作者：

Li, Wan-Fei ^{[1
]}

Wang, Juan ^{[2
,3
]}

Zhang, Jing-Jie ^{[1
]}

Song, Xun ^{[2
]}

Ku, Chuen-Fai ^{[2
]}

Zou, Juan ^{[1
]}

Li, Ji-Xin ^{[1
]}

Rong, Li-Jun ^{[4
]}

Pan, Lu-Tai ^{[1
]}

Zhang, Hong-Jie ^{[2
]}

机构：

[1] Guiyang Coll Tradit Chinese Med, Guiyang 550002, Peoples R China

[2] Hong Kong Baptist Univ, Sch Chinese Med, Kowloon, Hong Kong, Peoples R China

[3] Jilin Univ, Sch Publ Hlth, Changchun 130021, Peoples R China

[4] Univ Illinois, Coll Med, Dept Microbiol & Immunol, Chicago, IL 60612 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2015年 / 16卷 / 11期

关键词：

Pteris henryi; ent-kaurane diterpene; henrin A; bioactivity evaluation; anti-HIV activity; IMMUNODEFICIENCY-VIRUS TYPE-1; PURPUREORACHIS COPEL; RABDOSIA-RUBESCENS; CELLS; ORIDONIN; COMPONENTS; PRINCIPLE; FILICALES; PATHWAYS; AGENTS;

D O I：

10.3390/ijms161126071

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Henrin A (1), a new ent-kaurane diterpene, was isolated from the leaves of Pteris henryi. The chemical structure was elucidated by analysis of the spectroscopic data including one-dimensional (1D) and two-dimensional (2D) NMR spectra, and was further confirmed by X-ray crystallographic analysis. The compound was evaluated for its biological activities against a panel of cancer cell lines, dental bacterial biofilm formation, and HIV. It displayed anti-HIV potential with an IC50 value of 9.1 mu M (SI = 12.2).

引用

页码：27978 / 27987

页数：10

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