Henrin A: A New Anti-HIV Ent-Kaurane Diterpene from Pteris henryi

被引：16
|
作者：
Li, Wan-Fei [1 ]
Wang, Juan [2 ,3 ]
Zhang, Jing-Jie [1 ]
Song, Xun [2 ]
Ku, Chuen-Fai [2 ]
Zou, Juan [1 ]
Li, Ji-Xin [1 ]
Rong, Li-Jun [4 ]
Pan, Lu-Tai [1 ]
Zhang, Hong-Jie [2 ]
机构：
[1] Guiyang Coll Tradit Chinese Med, Guiyang 550002, Peoples R China
[2] Hong Kong Baptist Univ, Sch Chinese Med, Kowloon, Hong Kong, Peoples R China
[3] Jilin Univ, Sch Publ Hlth, Changchun 130021, Peoples R China
[4] Univ Illinois, Coll Med, Dept Microbiol & Immunol, Chicago, IL 60612 USA
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2015年 / 16卷 / 11期
关键词：
Pteris henryi; ent-kaurane diterpene; henrin A; bioactivity evaluation; anti-HIV activity; IMMUNODEFICIENCY-VIRUS TYPE-1; PURPUREORACHIS COPEL; RABDOSIA-RUBESCENS; CELLS; ORIDONIN; COMPONENTS; PRINCIPLE; FILICALES; PATHWAYS; AGENTS;
D O I：
10.3390/ijms161126071
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Henrin A (1), a new ent-kaurane diterpene, was isolated from the leaves of Pteris henryi. The chemical structure was elucidated by analysis of the spectroscopic data including one-dimensional (1D) and two-dimensional (2D) NMR spectra, and was further confirmed by X-ray crystallographic analysis. The compound was evaluated for its biological activities against a panel of cancer cell lines, dental bacterial biofilm formation, and HIV. It displayed anti-HIV potential with an IC50 value of 9.1 mu M (SI = 12.2).
引用
收藏
页码：27978 / 27987
页数：10
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