Blockade of adenosine A, receptors in the posterior cingulate cortex facilitates memory in rats

被引:38
|
作者
Pereira, GS
Souza, TME
Vinadé, ERC
Choi, H
Rodrigues, C
Battastini, AMO
Izquierdo, I
Sarkis, JJF
Bonan, CD
机构
[1] Pontificia Univ Catolica Rio Grande Do Sul, Dept Ciencias Fisiol, Fac Biociencias, BR-90619900 Porto Alegre, RS, Brazil
[2] Univ Fed Rio Grande do Sul, Inst Ciencias Basicas Saude, Dept Bioquim, Lab Enzimol, Porto Alegre, RS, Brazil
[3] Univ Fed Rio Grande do Sul, Inst Ciencias Basicas Saude, Dept Bioquim, Ctr Memoria, Porto Alegre, RS, Brazil
关键词
adenosine A(1) receptor; cortex; posterior cingulate; short-term memory; long-term memory;
D O I
10.1016/S0014-2999(02)01307-9
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Male Wistar rats were bilaterally implanted with indwelling cannulae in the caudal region of the posterior cingulate cortex. After recovery, animals were trained in a step-down inhibitory avoidance task (3.0-s, 0.4-mA foot shock) and received, immediately after training, a 0.5-mul infusion of the adenosine A(1) receptor agonist N6-cyclopentyladenosine (CPA; 1, 50 or 100 nM) or of the adenosine A(1) receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine (DPCPX; 1, 25 or 50 nM). Animals were tested twice, 1.5 h and, again, 24 h after training, in order to examine the effects of these agents on short- and long-term memory, respectively. Only 50-nM DPCPX was effective in altering memory, promoting a facilitation. These results suggest that adenosine A(1) receptors in the posterior cingulate cortex inhibit memory consolidation in a way that their blockade facilitates memory for inhibitory avoidance in rats. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:151 / 154
页数:4
相关论文
共 50 条
  • [21] Uncovering a tripartite landmark in posterior cingulate cortex
    Willbrand, Ethan H.
    Parker, Benjamin J.
    Voorhies, Willa I.
    Miller, Jacob A.
    Lyu, Ilwoo
    Hallock, Tyler
    Aponik-Gremillion, Lyndsey
    Koslov, Seth R.
    Bunge, Silvia A.
    Foster, Brett L.
    Weiner, Kevin S.
    SCIENCE ADVANCES, 2022, 8 (36):
  • [22] COMPARATIVE ASPECTS OF THE PRIMATE POSTERIOR CINGULATE CORTEX
    ARMSTRONG, E
    ZILLES, K
    SCHLAUG, G
    SCHLEICHER, A
    JOURNAL OF COMPARATIVE NEUROLOGY, 1986, 253 (04) : 539 - 548
  • [24] Echoes of the Brain within the Posterior Cingulate Cortex
    Leech, Robert
    Braga, Rodrigo
    Sharp, David J.
    JOURNAL OF NEUROSCIENCE, 2012, 32 (01): : 215 - 222
  • [25] Decision salience signals in posterior cingulate cortex
    Heilbronner, Sarah R.
    Hayden, Benjamin Y.
    Platt, Michael L.
    FRONTIERS IN NEUROSCIENCE, 2011, 5
  • [26] Cognitive control signals in posterior cingulate cortex
    Hayden, Benjamin Y.
    Smith, David V.
    Platt, Michael L.
    FRONTIERS IN HUMAN NEUROSCIENCE, 2010, 4
  • [27] Catastrophizing: Encodes Pain in Posterior cingulate cortex
    Brudermanns, Britta
    AKTUELLE RHEUMATOLOGIE, 2019, 44 (02) : 84 - +
  • [28] Saccade reward signals in posterior cingulate cortex
    McCoy, AN
    Crowley, JC
    Haghighian, G
    Dean, HL
    Platt, ML
    NEURON, 2003, 40 (05) : 1031 - 1040
  • [29] POSTERIOR CINGULATE CORTEX IN ALZHEIMERS-DISEASE
    MINOSHIMA, S
    FOSTER, NL
    KUHL, DE
    LANCET, 1994, 344 (8926): : 895 - 895
  • [30] Involvement of posterior cingulate cortex in ketamine-induced psychosis relevant behaviors in rats
    Ma, Jingyi
    Leung, L. Stan
    BEHAVIOURAL BRAIN RESEARCH, 2018, 338 : 17 - 27