Histamine and diabetic nephropathy: an up-to-date overview

被引：12

作者：

Pini, Alessandro ^{[1
]}

Verta, Roberta ^{[2
,3
]}

Grange, Cristina ^{[3
]}

Gurrieri, Maura ^{[2
]}

Rosa, Arianna Carolina ^{[2
]}

机构：

[1] Univ Florence, Dept Expt & Clin Med, Viale Pieraccini 6, I-50139 Florence, Italy

[2] Univ Turin, Dipartimento Sci & Tecnol Farmaco, Via P Giuria 9, I-10125 Turin, Italy

[3] Univ Turin, Dipartimento Sci Med, C So Dogliotti 14, I-10126 Turin, Italy

来源：

CLINICAL SCIENCE | 2019年 / 133卷 / 01期

关键词：

NECROSIS-FACTOR-ALPHA; EPITHELIAL-MYOFIBROBLAST TRANSDIFFERENTIATION; TISSUE FACTOR EXPRESSION; HUMAN-ENDOTHELIAL CELLS; GLYCATION END-PRODUCTS; CHRONIC KIDNEY-DISEASE; DOWN-REGULATION; MAST-CELLS; H-4; RECEPTOR; KAPPA-B;

D O I：

10.1042/CS20180839

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The classification of diabetic nephropathy (DN) as a vascular complication of diabetes makes the possible involvement of histamine, an endogenous amine that is well known for its vasoactive properties, an interesting topic for study. The aim of the present review is to provide an extensive overview of the possible involvement of histamine in the onset and progression of DN. The evidence collected on the role of histamine in kidney function together with its well-known pleiotropic action suggest that this amine may act simultaneously on glomerular hyperfiltration, tubular inflammation, fibrosis development and tubular hypertrophy.

引用

页码：41 / 54

页数：14

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