Catalytic asymmetric synthesis of the alkaloid (+)-myrtine

被引：44

作者：

Pizzuti, Maria Gabriefla ^{[1
]}

Minnaard, Adriaan J. ^{[1
]}

Feringa, Ben L. ^{[1
]}

机构：

[1] Univ Groningen, Stratingh Inst Chem, NL-9747 AG Groningen, Netherlands

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2008年 / 6卷 / 19期

关键词：

D O I：

10.1039/b807575a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new protocol for the asymmetric synthesis of trans-2,6-disubstituted-4-piperidones has been developed using a catalytic enantioselective conjugate addition reaction in combination with a diastereoselective lithiation-substitution sequence; an efficient synthesis of (+)-myrtine has been achieved via this route.

引用

页码：3464 / 3466

页数：3

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