Catalytic asymmetric synthesis of the alkaloid (+)-myrtine

被引：44
|
作者：
Pizzuti, Maria Gabriefla [1 ]
Minnaard, Adriaan J. [1 ]
Feringa, Ben L. [1 ]
机构：
[1] Univ Groningen, Stratingh Inst Chem, NL-9747 AG Groningen, Netherlands
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2008年 / 6卷 / 19期
关键词：
D O I：
10.1039/b807575a
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new protocol for the asymmetric synthesis of trans-2,6-disubstituted-4-piperidones has been developed using a catalytic enantioselective conjugate addition reaction in combination with a diastereoselective lithiation-substitution sequence; an efficient synthesis of (+)-myrtine has been achieved via this route.
引用
收藏
页码：3464 / 3466
页数：3
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