Requirement for croquemort in phagocytosis of apoptotic cells in Drosophila

被引：291
|
作者：
Franc, NC
Heitzler, P
Ezekowitz, RAB
White, K [1 ]
机构：
[1] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Cutaneous Biol Res Ctr, Charlestown, MA 02129 USA
[2] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Lab Dev Immunol, Charlestown, MA 02129 USA
[3] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Pediat, Charlestown, MA 02129 USA
[4] Univ Strasbourg 1, CNRS, INSERM, IGBMC, F-67404 Illkirch Graffenstaden, France
来源：
SCIENCE | 1999年 / 284卷 / 5422期
关键词：
D O I：
10.1126/science.284.5422.1991
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Macrophages in the Drosophila embryo are responsible for the phagocytosis of apoptotic cells and are competent to engulf bacteria. Croquemort (CRQ) is a CD36-related receptor expressed exclusively on these macrophages. Genetic evidence showed that crq was essential for efficient phagocytosis of apoptotic corpses but was not required for the engulfment of bacteria. The expression of CRQ was regulated by the amount of apoptosis. These data define distinct pathways for the phagocytosis of corpses and bacteria in Drosophila.
引用
收藏
页码：1991 / 1994
页数：4
相关论文
共 50 条
  • [31] Purification of a factor that enhances phagocytosis of apoptotic cells
    Allison, KC
    Henkart, PA
    FASEB JOURNAL, 1998, 12 (04): : A285 - A285
  • [32] Class A scavenger receptors and the phagocytosis of apoptotic cells
    Platt, N
    da Silva, RP
    Gordon, S
    IMMUNOLOGY LETTERS, 1999, 65 (1-2) : 15 - 19
  • [33] Phagocytosis of apoptotic cells during liver development
    Bernadette, Tenuzzo
    Zatta, Laura
    Dini, Luciana
    CARYOLOGIA, 2006, 59 (04) : 380 - 387
  • [34] A NOVEL METHOD TO ASSESS PHAGOCYTOSIS OF APOPTOTIC CELLS
    Komura, H.
    Miksa, M.
    Wu, R.
    Shah, K. G.
    Wang, P.
    SHOCK, 2009, 31 : 23 - 23
  • [35] Phagocytosis of apoptotic cells by liver:: A morphological study
    Dini, L
    Pagliara, P
    Carlà, EC
    MICROSCOPY RESEARCH AND TECHNIQUE, 2002, 57 (06) : 530 - 540
  • [36] Reduced phagocytosis of apoptotic cells in malignant lymphoma
    Hermann, M
    Niemitz, C
    Marafioti, T
    Schriever, F
    INTERNATIONAL JOURNAL OF CANCER, 1998, 75 (05) : 675 - 679
  • [37] In vivo analysis of phagocytosis of apoptotic cells by testicular Sertoli cells
    Nakagawa, A
    Shiratsuchi, A
    Tsuda, K
    Nakanishi, Y
    MOLECULAR REPRODUCTION AND DEVELOPMENT, 2005, 71 (02) : 166 - 177
  • [38] Phagocytosis of Apoptotic Cells by Neutrophil Granulocytes: Diminished Proinflammatory Neutrophil Functions in the Presence of Apoptotic Cells
    Esmann, Lars
    Idel, Christian
    Sarkar, Arup
    Hellberg, Lars
    Behnen, Martina
    Moeller, Sonja
    van Zandbergen, Ger
    Klinger, Matthias
    Koehl, Joerg
    Bussmeyer, Uta
    Solbach, Werner
    Laskay, Tamas
    JOURNAL OF IMMUNOLOGY, 2010, 184 (01): : 391 - 400
  • [39] Regulation of macrophage cytokine production by phagocytosis of apoptotic and post-apoptotic cells
    Fadok, VA
    McDonald, PP
    Bratton, DL
    Henson, PM
    BIOCHEMICAL SOCIETY TRANSACTIONS, 1998, 26 (04) : 653 - 656
  • [40] Carbocisteine promotes phagocytosis of apoptotic cells by alveolar macrophages
    Inoue, Masako
    Ishibashi, Yuji
    Nogawa, Hisashi
    Yasue, Tokutaro
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2012, 677 (1-3) : 173 - 179
12345