Requirement for croquemort in phagocytosis of apoptotic cells in Drosophila

被引：291
|
作者：
Franc, NC
Heitzler, P
Ezekowitz, RAB
White, K [1 ]
机构：
[1] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Cutaneous Biol Res Ctr, Charlestown, MA 02129 USA
[2] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Lab Dev Immunol, Charlestown, MA 02129 USA
[3] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Pediat, Charlestown, MA 02129 USA
[4] Univ Strasbourg 1, CNRS, INSERM, IGBMC, F-67404 Illkirch Graffenstaden, France
来源：
SCIENCE | 1999年 / 284卷 / 5422期
关键词：
D O I：
10.1126/science.284.5422.1991
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Macrophages in the Drosophila embryo are responsible for the phagocytosis of apoptotic cells and are competent to engulf bacteria. Croquemort (CRQ) is a CD36-related receptor expressed exclusively on these macrophages. Genetic evidence showed that crq was essential for efficient phagocytosis of apoptotic corpses but was not required for the engulfment of bacteria. The expression of CRQ was regulated by the amount of apoptosis. These data define distinct pathways for the phagocytosis of corpses and bacteria in Drosophila.
引用
收藏
页码：1991 / 1994
页数：4
相关论文
共 50 条
  • [1] Requirement for a Drosophila E3-ubiquitin ligase in phagocytosis of apoptotic cells
    Silva, Elizabeth
    Au-Yeung, Hiu Wan
    Van Goethem, Emeline
    Burden, Jemima
    Franc, Nathalie C.
    IMMUNITY, 2007, 27 (04) : 585 - 596
  • [2] Croquemort, a novel Drosophila hemocyte/macrophage receptor that recognizes apoptotic cells
    Franc, NC
    Dimarcq, JL
    Lagueux, M
    Hoffmann, J
    Ezekowitz, RAB
    IMMUNITY, 1996, 4 (05) : 431 - 443
  • [3] Phagocytosis Assay for Apoptotic Cells in Drosophila Embryos
    Nonaka, Saori
    Hori, Aki
    Nakanishi, Yoshinobu
    Kuraishi, Takayuki
    JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2017, (126):
  • [4] Identification of calreticulin as a marker for phagocytosis of apoptotic cells in Drosophila
    Kuraishi, Takayuki
    Manaka, Junko
    Kono, Mari
    Ishii, Hidenari
    Yamamoto, Naoko
    Koizumi, Keita
    Shiratsuchi, Akiko
    Lee, Bok Luel
    Higashida, Haruhiro
    Nakanishi, Yoshinobu
    EXPERIMENTAL CELL RESEARCH, 2007, 313 (03) : 500 - 510
  • [5] Integrin βν-mediated Phagocytosis of Apoptotic Cells in Drosophila Embryos
    Nagaosa, Kaz
    Okada, Ryo
    Nonaka, Saori
    Takeuchi, Kazuki
    Fujita, Yu
    Miyasaka, Tomoyuki
    Manaka, Junko
    Ando, Istvan
    Nakanishi, Yoshinobu
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (29) : 25770 - 25777
  • [6] Pretaporter, a Drosophila protein serving as a ligand for Draper in the phagocytosis of apoptotic cells
    Kuraishi, Takayuki
    Nakagawa, Yukiko
    Nagaosa, Kaz
    Hashimoto, Yumi
    Ishimoto, Takashi
    Moki, Takeshi
    Fujita, Yu
    Nakayama, Hiroshi
    Dohmae, Naoshi
    Shiratsuchi, Akiko
    Yamamoto, Naoko
    Ueda, Koichi
    Yamaguchi, Masamitsu
    Awasaki, Takeshi
    Nakanishi, Yoshinobu
    EMBO JOURNAL, 2009, 28 (24): : 3868 - 3878
  • [7] The phagocytosis of apoptotic cells
    Fadok, VA
    Chimini, G
    SEMINARS IN IMMUNOLOGY, 2001, 13 (06) : 365 - 372
  • [8] Phagocytosis of apoptotic cells
    Hart, Simon P.
    Dransfield, Ian
    Rossi, Adriano G.
    METHODS, 2008, 44 (03) : 280 - 285
  • [9] Integrin αPS3/βν-mediated Phagocytosis of Apoptotic Cells and Bacteria in Drosophila
    Nonaka, Saori
    Nagaosa, Kaz
    Mori, Toshinobu
    Shiratsuchi, Akiko
    Nakanishi, Yoshinobu
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 288 (15) : 10374 - 10380
  • [10] Methods for studying apoptosis and phagocytosis of apoptotic cells in Drosophila tissues and cell lines
    White, K
    Lisi, S
    Kurada, P
    Franc, N
    Bangs, P
    METHODS IN CELL BIOLOGY, VOL 66: APOPTOSIS, 2001, 66 : 321 - +
12345