Usnic Acid Derivatives Are Effective Inhibitors of Tyrosyl-DNA Phosphodiesterase 1

被引：19

作者：

Zakharenko, A. L. ^{[1
]}

Luzina, O. A. ^{[2
]}

Sokolov, D. N. ^{[2
]}

Zakharova, O. D. ^{[1
]}

Rakhmanova, M. E. ^{[3
]}

Chepanova, A. A. ^{[4
]}

Dyrkheeva, N. S. ^{[1
]}

Lavrik, O. I. ^{[1
,3
,4
]}

Salakhutdinov, N. F. ^{[2
,3
]}

机构：

[1] Russian Acad Sci, Siberian Branch, Inst Chem Biol & Fundamental Med, Novosibirsk 630090, Russia

[2] Russian Acad Sci, Siberian Branch, Vorozhtsov Novosibirsk Inst Organ Chem, Novosibirsk 630090, Russia

[3] Novosibirsk State Univ, Novosibirsk 630090, Russia

[4] Altai State Univ, Barnaul 656049, Russia

来源：

RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY | 2017年 / 43卷 / 01期

基金：

俄罗斯科学基金会;

关键词：

tyrosyl-DNA phosphodiesterase 1; tyrosyl-DNA phosphodiesterase 1 inhibitors; usnic acid; BIOLOGICAL EVALUATION; TDP1; IDENTIFICATION; ASSAY;

D O I：

10.1134/S1068162017010125

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of (+)-usnic acid derivatives is described. The derivatives contain one or two cyano groups, connected to the acetophenone fragment of dibenzofuran core by linkers of different length and character, or some other modifications. The influence of these compounds on the activity of recombinant human tyrosyl-DNA phosphodiesterase 1 and MCF-7 tumor cells' viability has been estimated. The data indicate a distinct dependence of functional characteristics of the compounds on their structure.

引用

页码：84 / 90

页数：7

共 50 条

[41] Aminoadamantanes containing monoterpene-derived fragments as potent tyrosyl-DNA phosphodiesterase 1 inhibitors
Ponomarev, Konstantin Yu.
Suslov, Evgeniy V.
Zakharenko, Alexandra L.
Zakharova, Olga D.
Rogachev, Artem D.
Korchagina, Dina V.
Zafar, Ayesha
Reynisson, Johannes
Nefedov, Andrey A.
Volcho, Konstantin P.
Salakhutdinov, Nariman F.
Lavrik, Olga I.
BIOORGANIC CHEMISTRY, 2018, 76 : 392 - 399
[42] Novel deazaflavin tyrosyl-DNA phosphodiesterase 2 (TDP2) inhibitors
Kiselev, Evgeny
Ravji, Azhar
Kankanala, Jayakanth
Xie, Jiashu
Wang, Zhengqiang
Pommier, Yves
DNA REPAIR, 2020, 85
[43] 3-Oxabicyclo[3.3.1]nonenes: synthesis and investigation as tyrosyl-DNA phosphodiesterase 1 inhibitors
Dyrkheeva, N. S.
Ilyina, I. V.
Volcho, K. P.
Salakhutdinov, N. F.
Lavrik, O. I.
RUSSIAN CHEMICAL BULLETIN, 2023, 72 (10) : 2525 - 2535
[44] 3-Oxabicyclo[3.3.1]nonenes: synthesis and investigation as tyrosyl-DNA phosphodiesterase 1 inhibitors
N. S. Dyrkheeva
I. V. Ilyina
K. P. Volcho
N. F. Salakhutdinov
O. I. Lavrik
Russian Chemical Bulletin, 2023, 72 : 2525 - 2535
[45] Synthesis and Biological Activities of 11-and 12-Substituted Benzophenanthridinone Derivatives as DNA Topoisomerase IB and Tyrosyl-DNA Phosphodiesterase 1 Inhibitors
Yang, Hao
Qin, Chao
Wu, Min
Wang, Fang-Ting
Wang, Wenjie
Agama, Keli
Pommier, Yves
Hu, De-Xuan
An, Lin-Kun
CHEMMEDCHEM, 2023,
[46] The crystal structure of human tyrosyl-DNA phosphodiesterase, Tdp1
Davies, DR
Interthal, H
Champoux, JJ
Hol, WGJ
STRUCTURE, 2002, 10 (02) : 237 - 248
[47] AP-site cleavage activity of tyrosyl-DNA phosphodiesterase 1
Lebedeva, Natalia A.
Rechkunova, Nadejda I.
Lavrik, Olga I.
FEBS LETTERS, 2011, 585 (04): : 683 - 686
[48] Substrate specificity of tyrosyl-DNA phosphodiesterase I (Tdp1)
Raymond, AC
Staker, BL
Burgin, AB
JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (23) : 22029 - 22035
[49] Virtual Screening for the Development of Dual-Inhibitors Targeting Topoisomerase IB and Tyrosyl-DNA Phosphodiesterase 1
Cardamone, Francesca
Pizzi, Simone
Iacovelli, Federico
Falconi, Mattia
Desideri, Alessandro
CURRENT DRUG TARGETS, 2017, 18 (05) : 544 - 555
[50] Tyrosyl-DNA phosphodiesterase 1 initiates repair of apurinic/apyrimidinic sites
Lebedeva, Natalia A.
Rechkunova, Nadejda I.
El-Khamisy, Sherif F.
Lavrik, Olga I.
BIOCHIMIE, 2012, 94 (08) : 1749 - 1753

← 1 2 3 4 5 →