High serum YKL-40 level positively correlates with coronary artery disease

被引：2
|
作者：
Jin, Yan [1 ]
Cao, Jia-Ning [1 ]
Wang, Chun-Xia [1 ]
Feng, Qiu-Ting [1 ]
Ye, Xin-He [1 ]
Xu, Xin [1 ]
Yang, Cheng-Jian [1 ]
机构：
[1] Nanjing Med Univ, WuXi Hosp 2, Dept Cardiol, 68 Zhongshan Rd, Wuxi 214002, Peoples R China
来源：
BIOMARKERS IN MEDICINE | 2017年 / 11卷 / 02期
关键词：
CAD; coronary artery disease; diagnosis; Gensini score; predictive value; ROC curve; sensitivity; serum; specificity; YKL-40; HEART-DISEASE; INFLAMMATORY BIOMARKER; PROMOTER REGION; PLASMA YKL-40; ATHEROSCLEROSIS; CHI3L1; MARKER; GENE; EXPRESSION; PREDICTION;
D O I：
10.2217/bmm-2016-024
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Aim: We investigated the predictive value of chitinase-like protein YKL-40 in coronary artery disease (CAD). Patients: Serum YKL-40 levels in 116 CAD patients and 82 healthy controls were analyzed. Severity of CAD was evaluated using Gensini scores. Spearman's correlation was used to evaluate the correlation between Gensini scores and YKL-40 levels. The predictive value of YKL-40 was determined by receivers operating characteristic curve analysis. Results: Serum YKL-40 levels were significantly elevated in CAD group as compared with control group. A positive correlation was found between the serum YKL-40 level and Gensini score. The optimum cut-off value of YKL-40 concentration was 127.7 ng/ ml for distinguishing CAD patients from healthy controls with a 75.9% sensitivity and 57.3% specificity. Conclusion: A positive correlation exists between YKL-40 levels and CAD, and YKL-40 might be a useful adjunct in the diagnosis of CAD.
引用
收藏
页码：133 / 139
页数：7
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