Urinary Intestinal Fatty Acid Binding Protein for Diagnosis of Necrotizing Enterocolitis

被引：2

作者：

Saran, Amarnath ^{[1
]}

Devegowda, Devananda ^{[2
]}

Doreswamy, Srinivasa Murthy ^{[1
]}

机构：

[1] JSS Acad Higher Educ & Res, JSS Med Coll, Dept Pediat, Mysuru, Karnataka, India

[2] JSS Acad Higher Educ & Res, JSS Med Coll, Dept Biochem, Mysuru, Karnataka, India

来源：

INDIAN PEDIATRICS | 2020年 / 57卷 / 09期

关键词：

Diagnostic marker; Necrotizing enterocolitis; Newborn; Bell criteria; Preterm; SEVERITY;

D O I：

10.1007/s13312-020-1955-y

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Objective This study was conducted to compare the urinary levels of intestinal fatty acid binding protein (I-FABP) and I-FABP: Cr (creatinine) between neonates with necrotising enterocolitis and gestation matched healthy controls. Methods 24 neonates with stage 1, 25 with stage 2 and 3 necrotizing enterocolitis, and 25 gestation matched (32.9 wk) controls were compared. Single spot urine sample was collected for estimating the IFABP and creatinine levels. Results Median (IQR) value of urinary I-FABP were higher in those with stage 2, 3 NEC [2773 (2417.7-2820)] than stage 1 NEC [1164 pg/mL (1341.5-2213.4)] and controls [413 (113-729.7); pg/mL] (P<0.001). Urinary I-FABP: Cr levels of 3.6 pg/mmoL had a sensitivity and specificity of 96% and 99.5%, respectively in diagnosing stage 2/3 NEC. Conclusion Urinary IFABP: Creatine ratio of 3.6 pg/mmoL is highly specific for stage 2 and 3 NEC.

引用

页码：798 / 800

页数：3

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