Urinary Intestinal Fatty Acid Binding Protein for Diagnosis of Necrotizing Enterocolitis

被引：2
|
作者：
Saran, Amarnath [1 ]
Devegowda, Devananda [2 ]
Doreswamy, Srinivasa Murthy [1 ]
机构：
[1] JSS Acad Higher Educ & Res, JSS Med Coll, Dept Pediat, Mysuru, Karnataka, India
[2] JSS Acad Higher Educ & Res, JSS Med Coll, Dept Biochem, Mysuru, Karnataka, India
来源：
INDIAN PEDIATRICS | 2020年 / 57卷 / 09期
关键词：
Diagnostic marker; Necrotizing enterocolitis; Newborn; Bell criteria; Preterm; SEVERITY;
D O I：
10.1007/s13312-020-1955-y
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Objective This study was conducted to compare the urinary levels of intestinal fatty acid binding protein (I-FABP) and I-FABP: Cr (creatinine) between neonates with necrotising enterocolitis and gestation matched healthy controls. Methods 24 neonates with stage 1, 25 with stage 2 and 3 necrotizing enterocolitis, and 25 gestation matched (32.9 wk) controls were compared. Single spot urine sample was collected for estimating the IFABP and creatinine levels. Results Median (IQR) value of urinary I-FABP were higher in those with stage 2, 3 NEC [2773 (2417.7-2820)] than stage 1 NEC [1164 pg/mL (1341.5-2213.4)] and controls [413 (113-729.7); pg/mL] (P<0.001). Urinary I-FABP: Cr levels of 3.6 pg/mmoL had a sensitivity and specificity of 96% and 99.5%, respectively in diagnosing stage 2/3 NEC. Conclusion Urinary IFABP: Creatine ratio of 3.6 pg/mmoL is highly specific for stage 2 and 3 NEC.
引用
收藏
页码：798 / 800
页数：3
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