A model of the large-scale organization of chromatin

被引：14

作者：

Barbieri, Mariano ^{[1
]}

Chotalia, Mita ^{[2
]}

Fraser, James ^{[3
,4
]}

Lavitas, Liron-Mark ^{[2
]}

Dostie, Josee ^{[3
,4
]}

Pombo, Ana ^{[2
]}

Nicodemi, Mario ^{[1
]}

机构：

[1] Univ Naples Federico II, Dipartimento Sci Fisiche, INFN Sez Napoli, CNR SPIN, I-80126 Naples, Italy

[2] Univ London Imperial Coll Sci Technol & Med, MRC Clin Sci Ctr, Genome Funct Grp, London W12 0NN, England

[3] McGill Univ, Dept Biochem, Montreal, PQ H3G 1Y6, Canada

[4] McGill Univ, Goodman Canc Res Ctr, Montreal, PQ H3G 1Y6, Canada

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2013年 / 41卷

基金：

英国医学研究理事会;

关键词：

chromatin organization; chromosome capture; polymer physics; self-organization; strings and binders switch model; thermodynamics; GENOME; TRANSITION;

D O I：

10.1042/BST20120238

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the cell nucleus, chromosomes have a complex spatial organization, spanning several length scales, which serves vital functional purposes. It is unknown, however, how their three-dimensional architecture is orchestrated. In the present article, we review the application of a model based on classical polymer physics, the strings and binders switch model, to explain the molecular mechanisms of chromatin self-organization. We explore the scenario where chromatin architecture is shaped and regulated by the interactions of chromosomes with diffusing DNA-binding factors via thermodynamics mechanisms and compare it with available experimental data.

引用

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页码：508 / 512

页数：5

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