PET with Fluorodeoxyglucose F 18/Computed Tomography as a Staging Tool in Multiple Myeloma

In the past decade novel treatment options have dramatically prolonged the survival of patients with multiple myeloma. PET combined with computed tomography (CT) is a sensitive and reliable functional imaging tool that enables diagnosis and assessment of response to chemotherapy/radiotherapy, and combines high sensitivity in identifying both lytic lesions and extramedullary soft-tissue masses with the ability to provide reliable prognostic information in the management of patients with myeloma. This review comprises a comprehensive overview of PET with fluorodeoxyglucose F 18/CT imaging in combination with other convenient imaging procedures, and attempts at standardization with emphasis on post-therapy findings in patients with myeloma.