Multilocus sequence typing (MLST) analysis of 104 Clostridium difficile strains isolated from China

被引：48
|
作者：
Yan, Q. [2 ]
Zhang, J. [3 ]
Chen, C. [2 ]
Zhou, H. [2 ]
Du, P. [2 ]
Cui, Z. [2 ]
Cen, R. [2 ]
Liu, L. [3 ]
Li, W. [2 ]
Cao, B. [2 ]
Lu, J. [1 ,2 ]
Cheng, Y. [1 ,2 ]
机构：
[1] China Ctr Dis Control & Prevent, Dept Hosp Acquired Infect Control & Prevent, State Key Lab Infect Dis Prevent & Control, Natl Inst Communicable Dis Control & Prevent, Beijing 102206, Peoples R China
[2] China Ctr Dis Control & Prevent, State Key Lab Infect Dis Prevent & Control SKLID, Beijing 102206, Peoples R China
[3] JiNan Municipal Ctr Dis Control & Prevent, Jinan, Shandong, Peoples R China
来源：
EPIDEMIOLOGY AND INFECTION | 2013年 / 141卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Clostridium difficile; gene polymorphism; MLST; POLYMERASE-CHAIN-REACTION; TOXIN; PCR; EMERGENCE; DISEASE; GENES;
D O I：
10.1017/S0950268812000453
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
The phylogenetic and epidemic relationships of 104 clinical isolates of Clostridium difficile from three hospitals of different geographical and population sources in China were investigated by multilocus sequence typing. Twenty-two sequence types (STs) were identified, four of which, ST117, ST118, ST119 and ST129, were novel. No geographically specific and host population-specific phylogenetic lineages were found and there was no correlation between geographical origin or host population and strain genotype. ST37 was the dominant type in our survey but the four novel STs underline the high genetic diversity and unique polymorphisms in C. difficile from China.
引用
收藏
页码：195 / 199
页数：5
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