Quantifying the Structural Dynamics of Pharmaceuticals in the Glassy State

被引：43

作者：

Wojnarowska, Z. ^{[1
]}

Roland, C. M. ^{[2
]}

Kolodziejczyk, K. ^{[1
]}

Swiety-Pospiech, A. ^{[1
]}

Grzybowska, K. ^{[1
]}

Paluch, M. ^{[1
]}

机构：

[1] Silesian Univ, Inst Phys, PL-40007 Katowice, Poland

[2] USN, Res Lab, Div Chem, Washington, DC 20375 USA

来源：

JOURNAL OF PHYSICAL CHEMISTRY LETTERS | 2012年 / 3卷 / 10期

关键词：

PROTIC IONIC LIQUIDS; DIELECTRIC RESPONSE; BETA-RELAXATION;

D O I：

10.1021/jz300349a

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Structural dynamics in the glassy state of two protic ionic liquids, carvedilol phosphate and procaine hydrochloride, were characterized from analysis of changes in the conductivity relaxation times during physical aging. The obtained a relaxation times, having a magnitude exceeding feasible experimental time scales and thus not directly measurable, are consistent with published data from a method that relies on the presence of a secondary relaxation. We also observe a narrowing of the relaxation dispersion, specific to higher frequencies, that is a consequence of the heterogeneous dynamics of deeply supercooled materials.

引用

页码：1238 / 1241

页数：4

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