In vivo imaging of extracellular matrix remodeling by tumor-associated fibroblasts

被引：0
|
作者：
Perentes, Jean Y. [1 ,2 ]
McKee, Trevor D. [1 ,2 ]
Ley, Carsten D. [1 ,2 ]
Mathiew, Hannah [1 ,2 ]
Dawson, Michelle [1 ,2 ]
Padera, Timothy P. [1 ,2 ]
Munn, Lance L. [1 ,2 ]
Jain, Rakesh K. [1 ,2 ]
Boucher, Yves [1 ,2 ]
机构：
[1] Massachusetts Gen Hosp, Dept Radiat Oncol, Boston, MA 02114 USA
[2] Harvard Univ, Sch Med, Boston, MA 02114 USA
来源：
NATURE METHODS | 2009年 / 6卷 / 02期
基金：
芬兰科学院;
关键词：
COLLAGEN; RELAXIN;
D O I：
10.1038/NMETH.1295
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Here we integrated multiphoton laser scanning microscopy and the registration of second harmonic generation images of collagen fibers to overcome difficulties in tracking stromal cell-matrix interactions for several days in live mice. We show that the matrix-modifying hormone relaxin increased tumor-associated fibroblast (TAF) interaction with collagen fibers by stimulating beta(1)-integrin activity, which is necessary for fiber remodeling by matrix metalloproteinases.
引用
收藏
页码：143 / 145
页数：3
相关论文
共 50 条
  • [41] Cancer Cell Invasion Driven by Extracellular Matrix Remodeling is Dependent on the Properties of Cancer-Associated Fibroblasts
    Neri, Shinya
    Date, Hiroshi
    Tsuboi, Masahiro
    Goto, Koichi
    Ochiai, Atsushi
    Ishii, Genichiro
    [J]. JOURNAL OF THORACIC ONCOLOGY, 2017, 12 (01) : S1119 - S1119
  • [42] Cancer cell invasion driven by extracellular matrix remodeling is dependent on the properties of cancer-associated fibroblasts
    Neri, Shinya
    Hashimoto, Hiroko
    Kii, Hiroaki
    Watanabe, Hirotada
    Masutomi, Kenkichi
    Kuwata, Takeshi
    Date, Hiroshi
    Tsuboi, Masahiro
    Goto, Koichi
    Ochiai, Atsushi
    Ishii, Genichiro
    [J]. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2016, 142 (02) : 437 - 446
  • [43] Cancer cell invasion driven by extracellular matrix remodeling is dependent on the properties of cancer-associated fibroblasts
    Shinya Neri
    Hiroko Hashimoto
    Hiroaki Kii
    Hirotada Watanabe
    Kenkichi Masutomi
    Takeshi Kuwata
    Hiroshi Date
    Masahiro Tsuboi
    Koichi Goto
    Atsushi Ochiai
    Genichiro Ishii
    [J]. Journal of Cancer Research and Clinical Oncology, 2016, 142 : 437 - 446
  • [44] Association of tumor-associated fibroblasts with progression of hepatocellular carcinoma
    Yang, Xiao-Yu
    Zhang, Dong
    Zou, Qi-Fei
    Fan, Fei
    Shen, Feng
    [J]. MEDICAL ONCOLOGY, 2013, 30 (03)
  • [45] Association of tumor-associated fibroblasts with progression of hepatocellular carcinoma
    Xiao-Yu Yang
    Dong Zhang
    Qi-Fei Zou
    Fei Fan
    Feng Shen
    [J]. Medical Oncology, 2013, 30
  • [46] Tumor-associated fibroblasts: Key players in cancer development
    Preunca, B.
    Thakur, N.
    Ilie, R.
    Bobilca, V
    Parikh, H.
    Mosteoru, S.
    Paunescu, V
    Bojin, F.
    Tatu, C.
    Gavriliuc, O.
    [J]. EUROPEAN JOURNAL OF MEDICAL RESEARCH, 2010, 15 : 217 - 217
  • [47] TUMOR-ASSOCIATED FIBROBLASTS: GENERIC TARGET OF CANCER IMMUNOTHERAPY
    Bojin, F.
    Gavriliuc, O.
    Paunescu, V.
    [J]. HUMAN GENE THERAPY, 2018, 29 (11) : A19 - A19
  • [48] Bone marrow contribution to tumor-associated myofibroblasts and fibroblasts
    Direkze, NC
    Hodivala-Dilke, K
    Jeffery, R
    Hunt, T
    Poulsom, R
    Oukrif, D
    Alison, MR
    Wright, NA
    [J]. CANCER RESEARCH, 2004, 64 (23) : 8492 - 8495
  • [49] Extracellular matrix stiffness and tumor-associated macrophage polarization: new fields affecting immune exclusion
    Yu, Ke-Xun
    Yuan, Wei-Jie
    Wang, Hui-Zhen
    Li, Yong-Xiang
    [J]. CANCER IMMUNOLOGY IMMUNOTHERAPY, 2024, 73 (06)
  • [50] Aptamers targeting a tumor-associated extracellular matrix component: The human mature collagen XIα1
    Lorenzo-Gomez, Ramon
    Miranda-Castro, Rebeca
    de los Toyos, Juan R.
    de-los-Santos-Alvarez, Noemi
    Lobo-Castanon, Maria Jesus
    [J]. ANALYTICA CHIMICA ACTA, 2022, 1189
12345