In vivo imaging of extracellular matrix remodeling by tumor-associated fibroblasts

被引：0
|
作者：
Perentes, Jean Y. [1 ,2 ]
McKee, Trevor D. [1 ,2 ]
Ley, Carsten D. [1 ,2 ]
Mathiew, Hannah [1 ,2 ]
Dawson, Michelle [1 ,2 ]
Padera, Timothy P. [1 ,2 ]
Munn, Lance L. [1 ,2 ]
Jain, Rakesh K. [1 ,2 ]
Boucher, Yves [1 ,2 ]
机构：
[1] Massachusetts Gen Hosp, Dept Radiat Oncol, Boston, MA 02114 USA
[2] Harvard Univ, Sch Med, Boston, MA 02114 USA
来源：
NATURE METHODS | 2009年 / 6卷 / 02期
基金：
芬兰科学院;
关键词：
COLLAGEN; RELAXIN;
D O I：
10.1038/NMETH.1295
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Here we integrated multiphoton laser scanning microscopy and the registration of second harmonic generation images of collagen fibers to overcome difficulties in tracking stromal cell-matrix interactions for several days in live mice. We show that the matrix-modifying hormone relaxin increased tumor-associated fibroblast (TAF) interaction with collagen fibers by stimulating beta(1)-integrin activity, which is necessary for fiber remodeling by matrix metalloproteinases.
引用
收藏
页码：143 / 145
页数：3
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