Fast condensation of cyclohexanone with 2-aminobenzonitrile at room temperature catalysed by an N-heterocyclic carbene

被引：8
|
作者：
Zhen, Bin [1 ]
Jiao, Qingze [1 ]
Zhang, Yaping [1 ]
Wu, Qin [1 ]
Li, Hansheng [1 ]
Shi, Daxin [1 ]
Li, Jiarong [1 ]
机构：
[1] Beijing Inst Technol, Sch Chem Engn & Environm, Beijing 100081, Peoples R China
来源：
CATALYSIS COMMUNICATIONS | 2013年 / 32卷
关键词：
N-heterocyclic carbene; Quinazolinone; Condensation; Cyclohexanone; 2-Aminobenzonitrile; ACID;
D O I：
10.1016/j.catcom.2012.11.029
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
A fast condensation of cyclohexanone with 2-aminobenzonitrile catalysed by N-heterocyclic carbene 1,3-dipropylimidazole-2-ylidene (NHC-PPIm) at room temperature was discovered. NHC-PPIm was prepared via concentration of a 1,3-dipropylimidazolium hydroxide aqueous solution and showed excellent catalytic activity in the condensation reaction for the synthesis of quinazolinone. A possible catalytic mechanism was proposed based on the umpolung of cyclohexanone. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码：1 / 4
页数：4
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