Microfluidics for cell factory and bioprocess development

被引：26
|
作者：
Bjork, Sara M. [1 ]
Joensson, Haakan N. [1 ]
机构：
[1] KTH Royal Inst Technol, Sch Chem Biotechnol & Hlth, Div Prot Sci, Stockholm, Sweden
来源：
CURRENT OPINION IN BIOTECHNOLOGY | 2019年 / 55卷
基金：
瑞典研究理事会;
关键词：
SINGLE-CELL; GENE SYNTHESIS; EVOLUTION; DEVICE; YEAST; OPTIMIZATION; CULTIVATION; BIOREACTOR; DROPLETS;
D O I：
10.1016/j.copbio.2018.08.011
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Bioindustry is expanding to an increasing variety of food, chemical and pharmaceutical products, each requiring rapid development of a dedicated cell factory and bioprocess. Microfluidic tools are, together with tools from synthetic biology and metabolic modeling, being employed in cell factory and bioprocess development to speed up development and address new products. Recent examples of microfluidics for bioprocess development range from integrated devices for DNA assembly and transformation, to high throughput screening of cell factory libraries, and micron scale bioreactors for process optimization. These improvements act to improve the biotechnological engineering cycle with tools for building, testing and evaluating cell factories and bioprocesses by increasing throughput, parallelization and automation.
引用
收藏
页码：95 / 102
页数：8
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