Is Iron Deficiency in the Absence of Anemia Associated With Fatigue in Inflammatory Bowel Disease?

被引:42
|
作者
Goldenberg, Benjamin A. [1 ]
Graff, Lesley A. [2 ,3 ]
Clara, Ian [3 ]
Zarychanski, Ryan [1 ,4 ]
Walker, John R. [2 ,3 ]
Carr, Rachel [3 ]
Rogala, Linda [3 ]
Miller, Norine [3 ]
Bernstein, Charles N. [1 ,3 ]
机构
[1] Univ Manitoba, Dept Internal Med, Winnipeg, MB R3E 3N4, Canada
[2] Univ Manitoba, Dept Clin Hlth Psychol, Winnipeg, MB R3E 3N4, Canada
[3] Univ Manitoba, IBD Clin & Res Ctr, Winnipeg, MB R3E 3N4, Canada
[4] Univ Manitoba, Dept Community Hlth Sci, Winnipeg, MB R3E 3N4, Canada
来源
AMERICAN JOURNAL OF GASTROENTEROLOGY | 2013年 / 108卷 / 09期
基金
加拿大健康研究院;
关键词
SERUM TRANSFERRIN RECEPTOR; QUALITY-OF-LIFE; CROHNS-DISEASE; NONANEMIC WOMEN; DIAGNOSIS; HEALTH; SUPPLEMENTATION; CHEMOTHERAPY; MANAGEMENT; FERRITIN;
D O I
10.1038/ajg.2013.14
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
OBJECTIVES: We explored whether iron deficiency in the absence of anemia is associated with fatigue in inflammatory bowel disease (IBD). METHODS: We assessed iron deficiency and anemia in 280 participants from the population-based Manitoba IBD Cohort Study. RESULTS: Iron deficiency was identified in 20% with Crohn's disease and 27% with ulcerative colitis. Anemia was identified overall in 50 (18%), with 230 who were nonanemic. In the nonanemic subgroup, there were no significant differences between iron-deficient and -sufficient groups in mean fatigue levels or proportions with problematic fatigue. There was no unique contribution of iron deficiency to problematic fatigue after adjustment for active disease and anemia. CONCLUSIONS: There was no evidence of an association between iron deficiency and fatigue in the absence of anemia, suggesting that iron deficiency is not a clinically relevant contributor to fatigue in IBD.
引用
收藏
页码:1392 / 1397
页数:6
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