Towards a general method for the stepwise solid-phase synthesis of peptide-oligonucleotide conjugates

被引：33

作者：

Antopolsky, M ^{[1
]}

Azhayeva, E ^{[1
]}

Tengvall, U ^{[1
]}

Azhayev, A ^{[1
]}

机构：

[1] Univ Kuopio, Dept Pharmaceut Chem, FIN-70211 Kuopio, Finland

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 03期

关键词：

D O I：

10.1016/S0040-4039(01)02185-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three peptide-oligonucleotide phosphorothioate hybrids were synthesized using a new approach for stepwise solid-phase synthesis of conjugates. This method utilizes commercially available N-x-Fmoc amino acids for peptide synthesis and a new solid support. Three specific modifications of the solid-phase were made after the peptide and before the oligonucleotide assembly. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：527 / 530

页数：4

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