p38γ and p38δ Mitogen Activated Protein Kinases (MAPKs), New Stars in the MAPK Galaxy

被引：55
|
作者：
Escos, Alejandra [1 ]
Risco, Ana [1 ]
Alsina-Beauchamp, Dayanira [1 ]
Cuenda, Ana [1 ]
机构：
[1] CSIC, Spanish Natl Res Council, Dept Immunol & Oncol, Ctr Nacl Biotecnol, Madrid, Spain
来源：
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2016年 / 4卷
关键词：
p38; gamma; delta; inflammation; innate response; CELLULAR STRESSES; P38; INFLAMMATION; PATHWAY; CANCER; MKK6; PHOSPHORYLATION; CYTOKINES; ISOFORMS; IMMUNITY;
D O I：
10.3389/fcell.2016.00031
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The protein kinases p38 gamma and p38 delta belong to the p38 mitogen-activated protein kinase (MAPK) family. p38MAPK signaling controls many cellular processes and is one of the most conserved mechanisms in eukaryotes for the cellular response to environmental stress and inflammation. Although p38 gamma and p38 delta are widely expressed, it is likely that they perform specific functions in different tissues. Their involvement in human pathologies such as inflammation-related diseases or cancer is starting to be uncovered. In this article we give a general overview and highlight recent advances made in defining the functions of p38 gamma and p38 delta, focusing in innate immunity and inflammation. We consider the potential of the pharmacological targeting of MAPK pathways to treat autoimmune and inflammatory diseases and cancer.
引用
收藏
页数：7
相关论文
共 50 条
  • [21] Phosphorylation of NFATc4 by p38 mitogen-activated protein kinases
    Yang, TTC
    Xiong, QF
    Enslen, H
    Davis, RJ
    Chow, CW
    MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (11) : 3892 - 3904
  • [22] The p38 mitogen-activated protein kinase (MAPK) pathway in rheumatoid arthritis
    Schett, G.
    Zwerina, J.
    Firestein, G.
    ANNALS OF THE RHEUMATIC DISEASES, 2008, 67 (07) : 909 - 916
  • [23] p38 mitogen-activated protein kinase (p38MAPK) is activated in the spinal microglia of neuropathic pain model
    Mizokoshi, A
    Tsuda, M
    Shigemoto-Mogami, Y
    Koizumi, S
    Inoue, K
    JAPANESE JOURNAL OF PHARMACOLOGY, 2002, 88 : 82P - 82P
  • [24] Role of p38 and p44/42 mitogen-activated protein kinases in microglia
    Koistinaho, M
    Koistinaho, J
    GLIA, 2002, 40 (02) : 175 - 183
  • [25] p38 mitogen-activated protein kinase and pain
    Mai, Lijia
    Zhu, Xiao
    Huang, Fang
    He, Hongwen
    Fan, Wenguo
    LIFE SCIENCES, 2020, 256
  • [26] p38 mitogen-activated protein kinase (p38 MAPK)-mediated autoimmunity: Lessons to learn from ANCA vasculitis and pemphigus vulgaris
    Mavropoulos, Athanasios
    Orfanidou, Timoklia
    Liaskos, Christos
    Smyk, Daniel S.
    Billinis, Charalambos
    Blank, Miri
    Rigopoulou, Eirini I.
    Bogdanos, Dimitrios P.
    AUTOIMMUNITY REVIEWS, 2013, 12 (05) : 580 - 590
  • [27] ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions
    Roux, PP
    Blenis, J
    MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 2004, 68 (02) : 320 - +
  • [28] JNK and p38 mitogen activated protein kinases are differentially activated following myocardial infarction in rabbits
    Jalili, T
    Carlstrom, J
    Litwin, S
    FASEB JOURNAL, 2002, 16 (05): : A1115 - A1115
  • [29] Heat Shock Factor 1 Is a Substrate for p38 Mitogen-Activated Protein Kinases
    Naidu, Sharadha Dayalan
    Sutherland, Calum
    Zhang, Ying
    Risco, Ana
    de la Vega, Laureano
    Caunt, Christopher J.
    Hastie, C. James
    Lamont, Douglas J.
    Torrente, Laura
    Chowdhry, Sudhir
    Benjamin, Ivor J.
    Keyse, Stephen M.
    Cuenda, Ana
    Dinkova-Kostova, Albena T.
    MOLECULAR AND CELLULAR BIOLOGY, 2016, 36 (18) : 2403 - 2417
  • [30] Activation of p38 and Erk Mitogen-Activated Protein Kinases Signaling in Ocular Rosacea
    Wladis, Edward J.
    Swamy, Supraja
    Herrmann, Alyssa
    Yang, Jinhong
    Carlson, J. Andrew
    Adam, Alejandro P.
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2017, 58 (02) : 843 - 848
12345