Quetiapine regulates the stress-induced increase in corticotropin-releasing factor mRNA expression in the rat hypothalamus

被引：5

作者：

Park, Sung-Woo

Lee, Sun-Kyung

Kim, Jae-Min

Kang, Ho-Cheol

Yoon, Jin-Sang

Kim, Young-Hoon

机构：

[1] Inje Univ, Dept Neuropsychiat, Sch Med, Paik Inje Mem Clin Res Inst, Pusan 614735, South Korea

[2] Chonnam Natl Univ, Sch Med, Dept Psychiat, Kwangju, South Korea

[3] Chonnam Natl Univ, Sch Med, Depress Clin Res Ctr, Kwangju, South Korea

[4] Chonnam Natl Univ, Sch Med, Dept Internal Med, Kwangju, South Korea

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2007年 / 31卷 / 02期

关键词：

animal model; corticotropin-releasing factor; depression; HPA axis; immobilization stress; quetiapine;

D O I：

10.1016/j.pnpbp.2006.09.011

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Corticotropin-releasing factor (CRF) is a key regulator of the stress response. We investigated the effects of the atypical antipsychotic drug quetiapine on CRF mRNA expression in the rat hypothalamus following immobilization stress. Pretreatment with 10 mg/kg quetiapine significantly reduced the immobilization stress-induced increase in CRF mRNA expression in the paraventricular nucleus of the hypothalamus. These results suggest that quetiapine may modulate the stress response via regulation of CRF mRNA expression. © 2006 Elsevier Inc. All rights reserved.

引用

页码：357 / 360

页数：4

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