Quetiapine regulates the stress-induced increase in corticotropin-releasing factor mRNA expression in the rat hypothalamus

被引：5
|
作者：
Park, Sung-Woo
Lee, Sun-Kyung
Kim, Jae-Min
Kang, Ho-Cheol
Yoon, Jin-Sang
Kim, Young-Hoon
机构：
[1] Inje Univ, Dept Neuropsychiat, Sch Med, Paik Inje Mem Clin Res Inst, Pusan 614735, South Korea
[2] Chonnam Natl Univ, Sch Med, Dept Psychiat, Kwangju, South Korea
[3] Chonnam Natl Univ, Sch Med, Depress Clin Res Ctr, Kwangju, South Korea
[4] Chonnam Natl Univ, Sch Med, Dept Internal Med, Kwangju, South Korea
来源：
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2007年 / 31卷 / 02期
关键词：
animal model; corticotropin-releasing factor; depression; HPA axis; immobilization stress; quetiapine;
D O I：
10.1016/j.pnpbp.2006.09.011
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Corticotropin-releasing factor (CRF) is a key regulator of the stress response. We investigated the effects of the atypical antipsychotic drug quetiapine on CRF mRNA expression in the rat hypothalamus following immobilization stress. Pretreatment with 10 mg/kg quetiapine significantly reduced the immobilization stress-induced increase in CRF mRNA expression in the paraventricular nucleus of the hypothalamus. These results suggest that quetiapine may modulate the stress response via regulation of CRF mRNA expression. © 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码：357 / 360
页数：4
相关论文
共 50 条
  • [1] Biting suppresses stress-induced expression of corticotropin-releasing factor (CRF) in the rat hypothalamus
    Hori, N
    Yuyama, N
    Tamura, K
    JOURNAL OF DENTAL RESEARCH, 2004, 83 (02) : 124 - 128
  • [2] STRESS-INDUCED INCREASE IN VASOPRESSIN AND CORTICOTROPIN-RELEASING FACTOR EXPRESSION IN HYPOPHYSIOTROPHIC PARAVENTRICULAR NEURONS
    BARTANUSZ, V
    JEZOVA, D
    BERTINI, LT
    TILDERS, FJH
    AUBRY, JM
    KISS, JZ
    ENDOCRINOLOGY, 1993, 132 (02) : 895 - 902
  • [3] Age- and stress-induced changes in corticotropin-releasing hormone mRNA expression in the paraventricular nucleus of the hypothalamus
    Romeo, Russell D.
    Karatsoreos, Ilia N.
    Jasnow, Aaron M.
    McEwen, Bruce S.
    NEUROENDOCRINOLOGY, 2007, 85 (04) : 199 - 206
  • [4] Increased expression of corticotropin-releasing factor receptor mRNA in the locus coeruleus of stress-induced rat model of depression
    Zeng, J
    Kitayama, I
    Yoshizato, H
    Zhang, K
    Okazaki, Y
    LIFE SCIENCES, 2003, 73 (09) : 1131 - 1139
  • [5] CORTICOTROPIN-RELEASING FACTOR AND STRESS-INDUCED GASTROINTESTINAL ALTERATIONS
    BUENO, L
    GASTROENTEROLOGY, 1989, 97 (01) : 240 - 240
  • [6] STRESS-INDUCED CHANGES IN CORTICOTROPIN-RELEASING FACTOR (CRF)
    BIRKLE, DL
    WARD, HE
    CRATTY, MS
    LEONARD, EM
    AZZARO, AJ
    JOURNAL OF NEUROCHEMISTRY, 1994, 62 : S98 - S98
  • [7] ANTAGONIST TO CORTICOTROPIN-RELEASING FACTOR BLOCKS STRESS-INDUCED IMMUNOSUPPRESSION
    JAIN, R
    AUDHYA, T
    HUTCHINSON, B
    BROWN, C
    HOLLANDER, CS
    CLINICAL RESEARCH, 1989, 37 (02): : A533 - A533
  • [8] Amygdalar corticotropin-releasing factor mediates stress-induced anxiety
    Ventura-Silva, Ana Paula
    Borges, Sonia
    Sousa, Nuno
    Rodrigues, Ana Joao
    Pego, Jose Miguel
    BRAIN RESEARCH, 2020, 1729
  • [9] Repeated restraint stress-induced increase in baroreceptor reflex sensitivity: Role of corticotropin-releasing factor
    Conti, LH
    Shannon, MH
    Murry, JD
    Printz, MP
    NEUROPEPTIDES, 2001, 35 (02) : 71 - 81
  • [10] Corticotropin-releasing factor is involved in acute stress-induced analgesia and antipruritus
    Wang, Xiao-Dong
    Bai, Hao-Miao
    Li, Xiao-Lan
    Zhang, Lin-Fang
    Li, Fei
    Bai, Yang
    Wu, Zhen-Yu
    Liu, Shang-Qing
    Li, Hui
    BRAIN AND BEHAVIOR, 2022, 12 (11):
12345