The role of vascular endothelial protein tyrosine phosphatase on nitric oxide synthase function in diabetes: from molecular biology to the clinic

被引：5

作者：

Justo, Alberto Fernando Oliveira ^{[1
]}

Afonso, Pedro Paulo Luciano ^{[2
]}

机构：

[1] Fed Univ Sao Paulo UNIFESP, Dept Med, Sao Paulo, SP, Brazil

[2] Hosp Municipal Campo Limpo, Sao Paulo, SP, Brazil

来源：

JOURNAL OF CELL COMMUNICATION AND SIGNALING | 2021年 / 15卷 / 03期

关键词：

AKB-9778; VE-PTP; eNOS; eNOS tyrosine phosphorylation; eNOS serine phosphorylation;

D O I：

10.1007/s12079-021-00611-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Endothelial nitric oxide synthase (eNOS) and receptor-type vascular endothelial protein tyrosine phosphatase (VE-PTP) are one of the majors signaling pathways related to endothelial health in diabetes. Several reports have shown that the inhibition of VE-PTP can lead the nitric oxide production, although repeated studies showed that VE-PTP regulated the eNOS exclusive at Ser1177 in indirect-manner. A recent, exciting paper (Siragusa et al. in Cardiovasc Res, 2020. ), showing that VE-PTP regulates eNOS in a direct-manner, dephosphorylating eNOS at Tyr81 and indirect at Ser1177 and the effects of a VE-PTP inhibitor, AKB-9778, in the blood pressure from diabetic patients.

引用

页码：467 / 471

页数：5

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