The role of vascular endothelial protein tyrosine phosphatase on nitric oxide synthase function in diabetes: from molecular biology to the clinic

被引：5
|
作者：
Justo, Alberto Fernando Oliveira [1 ]
Afonso, Pedro Paulo Luciano [2 ]
机构：
[1] Fed Univ Sao Paulo UNIFESP, Dept Med, Sao Paulo, SP, Brazil
[2] Hosp Municipal Campo Limpo, Sao Paulo, SP, Brazil
来源：
JOURNAL OF CELL COMMUNICATION AND SIGNALING | 2021年 / 15卷 / 03期
关键词：
AKB-9778; VE-PTP; eNOS; eNOS tyrosine phosphorylation; eNOS serine phosphorylation;
D O I：
10.1007/s12079-021-00611-9
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Endothelial nitric oxide synthase (eNOS) and receptor-type vascular endothelial protein tyrosine phosphatase (VE-PTP) are one of the majors signaling pathways related to endothelial health in diabetes. Several reports have shown that the inhibition of VE-PTP can lead the nitric oxide production, although repeated studies showed that VE-PTP regulated the eNOS exclusive at Ser1177 in indirect-manner. A recent, exciting paper (Siragusa et al. in Cardiovasc Res, 2020. ), showing that VE-PTP regulates eNOS in a direct-manner, dephosphorylating eNOS at Tyr81 and indirect at Ser1177 and the effects of a VE-PTP inhibitor, AKB-9778, in the blood pressure from diabetic patients.
引用
收藏
页码：467 / 471
页数：5
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