Emergence of Pseudomonas aeruginosa strains producing metallo-β-lactamases of the IMP-15 and VIM-2 types in Mexico

被引：26
|
作者：
Quinones-Falconi, F. [2 ]
Galicia-Velasco, M. [2 ]
Marchiaro, P. [1 ]
Mussi, M. A. [1 ]
Ballerini, V. [4 ]
Vila, A. J. [3 ]
Viale, A. M. [1 ]
Bermejo-Morales, K. [2 ]
Limansky, A. S. [1 ]
机构：
[1] Univ Nacl Rosario, Dept Microbiol, Inst Biol Mol & Celular Rosario, CONICET,Fac Ciencias Bioquim & Farmaceut, RA-2000 Rosario, Santa Fe, Argentina
[2] Inst Nacl Enfermedades Resp, Serv Microbiol Clin, Mexico City, DF, Mexico
[3] Univ Nacl Rosario, Dept Quim Biol, Inst Biol Mol & Celular Rosario, CONICET,Fac Ciencias Bioquim & Farmaceut, RA-2000 Rosario, Santa Fe, Argentina
[4] Hosp Intendente Carrasco, Dept Bioquim Municipal, Secretaria Salud Publ, Rosario, Santa Fe, Argentina
来源：
CLINICAL MICROBIOLOGY AND INFECTION | 2010年 / 16卷 / 02期
关键词：
Carbapenem resistance; IMP-15; metallo-beta-lactamases; Pseudomonas aeruginosa; VIM-2; GRAM-NEGATIVE PATHOGENS; CLASS-1; INTEGRON; UNITED-STATES; RESISTANCE; BLA(VIM-2); BACTERIA; GENE;
D O I：
10.1111/j.1469-0691.2009.02780.x
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Eighty-six carbapenem non-susceptible Pseudomonas aeruginosa isolates collected in the National Institute of Respiratory Diseases of Mexico City were screened for the presence of metallo-beta-lactamase (MBL) activity using both E-test strips and a microbiological assay with EDTA-imipenem. Genomic comparisons and sequence analyses conducted with these isolates revealed the presence of bla(VIM-2) in two clonally related isolates, and bla(IMP-15) in a clonally unrelated isolate. Both genes were found to be carried by class 1 integrons, and bla(IMP-15) was additionally present on a broad host-range plasmid. This is the first report of co-existing P. aeruginosa strains producing different MBLs in a Mexican hospital, highlighting the necessity of appropriate surveillance to prevent dissemination of carbapenem resistance.
引用
收藏
页码：126 / 131
页数：6
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