Discovery of 8-hydroxyadenines as a novel type of interferon inducer

被引：75

作者：

Hirota, K ^{[1
]}

Kazaoka, K

Niimoto, I

Kumihara, H

Sajiki, H

Isobe, Y

Takaku, H

Tobe, M

Ogita, H

Ogino, T

Ichii, S

Kurimoto, A

Kawakami, H

机构：

[1] Gifu Pharmaceut Univ, Med Chem Lab, Gifu 5028585, Japan

[2] Japan Energy Corp, Pharmaceut & Biotechnol Lab, Toda, Saitama 3350026, Japan

[3] Sumitomo Pharmaceut, Div Res, Konohana Ku, Osaka 5540022, Japan

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2002年 / 45卷 / 25期

关键词：

D O I：

10.1021/jm0203581

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

9-Benzyl-8-hydroxyadenine (6) was found to possess interferon-inducing activity in vitro as a lead compound. Although replacement of the 9-benzyl group of 6 did not improve the activity, the introduction of a substituent such as alkyl, alkylthio, alkylamino, and alkoxy groups into the 2-position of the adenine ring resulted in a remarkable increase in the activity. The 2-alkylthio (30-32), 2-butylamino (41), and 2-butoxy (47) analogues indicated the highest activities by oral administration to mice.

引用

页码：5419 / 5422

页数：4

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