Thermodynamics of partitioning of some sulfonamides in 1-octanol-buffer and liposome systems

被引：36
|
作者：
Martínez, F
Gómez, A
机构：
[1] Univ Nacl Colombia, Dept Pharm, AA-14490 Bogota, Colombia
[2] Univ Nacl Colombia, Dept Chem, AA-14490 Bogota, Colombia
来源：
JOURNAL OF PHYSICAL ORGANIC CHEMISTRY | 2002年 / 15卷 / 12期
关键词：
sulfonamides; partition coefficient; liposomes; l-octanol; thermodynamics of transfer;
D O I：
10.1002/poc.564
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The thermodynamics of partitioning of some structurally related sulfonamides have been determined in 1-octanol-aqueous buffer and liposome systems. The partition coefficients were approximately tenfold higher in liposomes compared with I-octanol. The enthalpies of transfer from aqueous media to organic systems were positive in liposomes but negative or positive in 1-octanol, whereas the entropies of transfer were positive in almost all cases. Copyright (C) 2002 John Wiley Sons, Ltd.
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收藏
页码：874 / 880
页数：7
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