Direct co-crystal assembly from synthesis to co-crystallization

被引：11
|
作者：
Lee, Hung Lin [1 ]
Lee, Tu [1 ]
机构：
[1] Natl Cent Univ, Dept Chem & Mat Engn, Jhong Li City 320, Taiwan
来源：
CRYSTENGCOMM | 2015年 / 17卷 / 47期
关键词：
ACTIVE PHARMACEUTICAL INGREDIENT; IN-SITU; COVALENT ASSISTANCE; SCALE-UP; SOLUBILITY; CRYSTALLIZATION; SOLVENT; ASPIRIN; STOICHIOMETRY; FUNCTIONALITY;
D O I：
10.1039/c5ce01205h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Pharmaceutical co-crystals were assembled directly via chemical synthesis by cooling under three new strategies. The screening method for direct co-crystal assembly by a chemical reaction was developed based on liquid-assisted grinding. The ternary phase diagram including a chemical reaction and co-crystallization was established for a 2 : 1 co-crystal of benzoic acid-sodium benzoate.
引用
收藏
页码：9002 / 9006
页数：5
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