mdr1 ribozyme mediated reversal of the multi-drug resistant phenotype in human lung cell lines

被引：12

作者：

Daly, C ^{[1
]}

Coyle, S ^{[1
]}

McBride, S ^{[1
]}

ODriscoll, L ^{[1
]}

Daly, N ^{[1
]}

Scanlon, K ^{[1
]}

Clynes, M ^{[1
]}

机构：

[1] BERLEX BIOSCI, RICHMOND, CA 94804 USA

来源：

CYTOTECHNOLOGY | 1996年 / 19卷 / 03期

关键词：

human lung lines; drug resistance; mdr1; ribozyme;

D O I：

10.1007/BF00744213

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

An mdr1 hammerhead was introduced into two adriamycin-selected multi-drug resistant human lung cell lines both of which over-express p-glycoprotein. Expression of the ribozyme resulted in a decrease in mdr1 mRNA expression and an increase in drug sensitivity in both cell lines. This would suggest that the use of specific ribozymes may represent an effective and specific approach in order to restore cellular sensitivity towards anti-cancer drugs.

引用

页码：199 / 205

页数：7

共 50 条

[41] Sensitization of multidrug-resistant human leukemia cells with MDR1-targeted antisense and inhibition of drug-mediated MDR1 induction
Li, X
Smyth, AP
Barrett, DJ
Ivy, SP
vonHofe, E
LEUKEMIA, 1997, 11 (07) : 950 - 957
[42] Multi-drug resistance and breast cancer: A meta-analysis of MDR1 and its functional significance
Trock, B.
Leonessa, F.
Clarke, R.
JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (18)
[43] Induction of apoptosis by modulation of ceramide metabolism in multi-drug resistant human leukemia cell lines.
Kitano, T
Okazaki, T
Tashima, M
Uchiyama, T
BLOOD, 1998, 92 (10) : 165B - 165B
[44] MDR1 EXPRESSION IN HUMAN LEUKEMIA-LYMPHOMA CELL-LINES
METGE, K
STEUBE, K
UPHOFF, CC
GIGNAC, SM
DREXLER, HG
LEUKEMIA, 1993, 7 (06) : 896 - 897
[45] Overexpression of drug resistance genes MDR1 and cMOAT in human hepatocellular carcinoma and hepatoblastoma cell lines.
Minemura, M
Tanimura, H
Tabor, E
HEPATOLOGY, 1997, 26 (04) : 181 - 181
[46] Drug resistance conferred by MDR1 expression in spheroids formed by glioblastoma cell lines
Kolchinsky, A
Roninson, IB
ANTICANCER RESEARCH, 1997, 17 (5A) : 3321 - 3327
[47] Differential modulation of nuclear texture, histone acetylation, and MDR1 gene expression in human drug-sensitive and -resistant OV1 cell lines
Yatouji, Sonia
El-Khoury, Victoria
Trentesaux, Chantal
Trussardi-Regnier, Aurelie
Benabid, Rym
Bontems, Franck
Dufer, Jean
INTERNATIONAL JOURNAL OF ONCOLOGY, 2007, 30 (04) : 1003 - 1009
[48] Relationship between Methylation Status of Multi-drug Resistance Protein(MRP) and Multi-drug Resistance in Lung Cancer Cell Lines
柳瑞军
钟竑
Chinese Journal of Cancer Research, 2007, (04) : 277 - 282
[49] Relationship between Methylation Status of Multi-drug Resistance Protein (MRP) and Multi-drug Resistance in Lung Cancer Cell Lines
Li, Hong
Zhu, Yi-Fei
Zheng, Shi-Ying
Jiang, Dong
2009 INTERNATIONAL CONFERENCE ON FUTURE BIOMEDICAL INFORMATION ENGINEERING (FBIE 2009), 2009, : 548 - +
[50] Relationship between methylation status of multi-drug resistance protein(MRP) and multi-drug resistance in lung cancer cell lines
Liu Rui-jun
Zhong Hong
CHINESE JOURNAL OF CANCER RESEARCH, 2007, 19 (04) : 277 - 282

← 1 2 3 4 5 →