mdr1 ribozyme mediated reversal of the multi-drug resistant phenotype in human lung cell lines

被引：12
|
作者：
Daly, C [1 ]
Coyle, S [1 ]
McBride, S [1 ]
ODriscoll, L [1 ]
Daly, N [1 ]
Scanlon, K [1 ]
Clynes, M [1 ]
机构：
[1] BERLEX BIOSCI, RICHMOND, CA 94804 USA
来源：
CYTOTECHNOLOGY | 1996年 / 19卷 / 03期
关键词：
human lung lines; drug resistance; mdr1; ribozyme;
D O I：
10.1007/BF00744213
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
An mdr1 hammerhead was introduced into two adriamycin-selected multi-drug resistant human lung cell lines both of which over-express p-glycoprotein. Expression of the ribozyme resulted in a decrease in mdr1 mRNA expression and an increase in drug sensitivity in both cell lines. This would suggest that the use of specific ribozymes may represent an effective and specific approach in order to restore cellular sensitivity towards anti-cancer drugs.
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页码：199 / 205
页数：7
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