The emerging role of long non-coding RNAs in endometrial cancer

被引：44

作者：

Takenaka, Konii ^{[1
]}

Chen, Bei Jun ^{[1
]}

Modesitt, Susan C. ^{[2
]}

Byrne, Frances L. ^{[1
]}

Hoehn, Kyle L. ^{[1
]}

Janitz, Michael ^{[1
]}

机构：

[1] Univ New South Wales, Sch Biotechnol & Biomol Sci, Sydney, NSW 2052, Australia

[2] Univ Virginia Hlth Syst, Dept Obstet & Gynecol, Div Gynecol Oncol, Charlottesville, VA 22908 USA

来源：

CANCER GENETICS | 2016年 / 209卷 / 10期

关键词：

Endometrial cancer; long non-coding RNAs; transcriptome; gene expression; lincRNAs; CIRCULAR RNA; EXPRESSION PROFILE; POOR-PROGNOSIS; ALLELIC LOSS; CARCINOMA; GENE; H19; HOTAIR; RISK; IMMUNOHISTOCHEMISTRY;

D O I：

10.1016/j.cancergen.2016.09.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The human genome is pervasively transcribed and approximately 98% of the genome is non coding. Long non-coding RNAs (IncRNAs) are a heterogeneous group of RNA transcripts that are >200 nucleotides in length with minimal to no protein-coding potential. Similar to proteins, IncRNAs have important biological functions in both normal cells and disease states including many types of cancer. This review summarizes recent advances in our understanding of IncRNAs in cancer biology and highlights the potential for IncRNA as diagnostic biomarkers and therapeutics. Herein we focus on the poorly understood role of IncRNAs in endometrial cancer, the most common gynecologic malignancy in the developed world.

引用

页码：445 / 455

页数：11

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