Synthesis and alkylation of pyrazolo[3,4-c]isoquinolines and hexahydrocyclohepta[d]pyrazolo[3,4-b]pyridines

被引：4
|
作者：
Dyachenko, I. V. [1 ]
Rusanov, E. B. [2 ]
Vovk, M. V. [2 ]
机构：
[1] Taras Shevchenko Lugansk Nats Univ, UA-91011 Lugansk, Ukraine
[2] Natl Acad Sci Ukraine, Inst Organ Chem, UA-02660 Kiev, Ukraine
来源：
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 49卷 / 09期
关键词：
DERIVATIVES;
D O I：
10.1134/S1070428013090224
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The condensation of 1-acyl-2-(morpholin-4-yl)cycloalkenes with 3-amino-1-phenyl-1H-pyrazol-5(4H)-ones gave the corresponding 2,3,6,7,8,9-hexahydropyrazolo[3,4-c]isoquinoline and 3,6,7,8,9,10-hexahydrocyclohepta[ d]pyrazolo[3,4-b]pyridine derivatives. Alkylation of 2,3,6,7,8,9-hexahydropyrazolo[3,4-c]-isoquinolines with alkyl halides occurred at the nitrogen atom in the 3-position. The structure of 7-methyl-2,5-diphenyl-2,3,6,7,8,9-hexahydro-1H-pyrazolo[3,4-c]isoquinolin-1-one was proved by X-ray analysis.
引用
收藏
页码：1364 / 1368
页数：5
相关论文
共 50 条
  • [21] STUDY OF STRUCTURE OF INDAZOLES, PYRAZOLO[3,4-B]PYRIDINES AND PYRAZOLO[3,4-B]PYRAZINE BY MEANS OF IR SPECTROSCOPY
    SENNITSKAYA, LB
    TIMOSHENKOVA, YD
    KIKOT, BS
    PENTIN, YA
    BLANKO, FF
    KORBUKH, IA
    PREOBRAZHENSKAYA, MN
    [J]. KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 1977, (05): : 662 - 667
  • [22] Synthesis of some new pyrazolo[3,4-d]pyrimidines and pyrazolo[3,4-c]pyrazoles
    Ahluwalia, VK
    Dahiya, A
    Bala, M
    [J]. INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 1996, 35 (08): : 848 - 851
  • [23] SYNTHESIS AND BIOLOGICAL EVALUATION OF XANTHINE-OXIDASE INHIBITORS - PYRAZOLO[3,4-D]PYRIMIDINES AND PYRAZOLO[3,4-B]PYRIDINES
    CHU, I
    LYNCH, BM
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1975, 18 (02) : 161 - 165
  • [24] Synthesis of some novel fluorinated pyrazolo[3,4-b]pyridines
    Singh, SP
    Naithani, R
    Aggarwal, R
    Prakash, O
    [J]. SYNTHETIC COMMUNICATIONS, 2004, 34 (23) : 4359 - 4367
  • [25] SYNTHESIS OF PYRAZOLO[3,4-B][1,4]DIAZEPINES AND PYRAZOLO[3,4-B]PYRAZINES
    COLOMBO, A
    FRIGOLA, J
    PARES, J
    ANDALUZ, B
    [J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 1989, 26 (04) : 949 - 955
  • [26] Synthesis of new pyrazolo[1,5-α]pyrimidines and pyrazolo[3,4-b]pyridines
    Al-Mousawi, SM
    Mohammad, MA
    Elnagdi, MH
    [J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 2001, 38 (04) : 989 - 991
  • [27] A convenient route for the synthesis of pyrazolo[3,4-d]pyrimidine, pyrazolo[3,4-b][1,6]naphthyridine and pyrazolo[3,4-b]quinoline derivatives
    Jachak, Madhukar N.
    Avhale, Appasaheb B.
    Medhane, Vijay J.
    Toche, Raghunath B.
    [J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 2006, 43 (05) : 1169 - 1175
  • [28] Synthesis and anticonvulsant activity of pyrazolo[3,4-b]pyrano(thiopyrano)[4,3-d]pyridine and pyrazolo[3,4-c]isoquinoline derivatives
    Paronikyan E.G.
    Sirakanyan S.N.
    Noravyan A.S.
    Paronikyan R.G.
    Dzhagatspanyan I.A.
    [J]. Pharmaceutical Chemistry Journal, 2001, 35 (1) : 8 - 10
  • [29] SYNTHESIS OF PYRAZOLO[3,4-C]ISOQUINOLINE AND PYRAZOLO[3,4-B]PYRIDINE DERIVATIVES FROM AZOMETHINES AND CH-ACIDIC COMPOUNDS
    HENNIG, L
    ALVAASTUDILLO, M
    MEUSINGER, R
    MANN, G
    [J]. MONATSHEFTE FUR CHEMIE, 1993, 124 (8-9): : 893 - 898
  • [30] NEW ROUTE FOR THE PREPARATION OF PYRAZOLO[3,4-C]PYRIDINES
    MIGLIARA, O
    PETRUSO, S
    SPRIO, V
    [J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 1979, 16 (03) : 577 - 579
12345