Dense Genomewide Linkage Scan for Alcohol Dependence in African Americans: Significant Linkage on Chromosome 10

被引:29
|
作者
Gelernter, Joel [1 ,2 ,3 ]
Kranzler, Henry R. [4 ]
Panhuysen, Carolien [5 ,6 ]
Weiss, Roger D. [7 ,8 ]
Brady, Kathleen [9 ]
Poling, James [1 ,3 ]
Farrer, Lindsay [5 ,6 ]
机构
[1] Yale Univ, Sch Med, Div Human Genet, Dept Psychiat, West Haven, CT 06516 USA
[2] Yale Univ, Sch Med, Div Human Genet, Dept Neurobiol & Genet, West Haven, CT 06516 USA
[3] Vet Adm Connecticut Healthcare Ctr, West Haven, CT USA
[4] Univ Connecticut, Sch Med, Dept Psychiat, Farmington, CT USA
[5] Boston Univ, Sch Med, Genet Program, Dept Med, Boston, MA 02215 USA
[6] Boston Univ, Sch Med, Sch Publ Hlth, Dept Biostat, Boston, MA 02215 USA
[7] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA
[8] McLean Hosp, Alcohol & Drug Abuse Treatment Program, Belmont, MA 02178 USA
[9] Med Univ S Carolina, Dept Psychiat, Charleston, SC 29425 USA
基金
美国国家卫生研究院;
关键词
Alcohol dependence; African American population; genomewide linkage; substance dependence genetics; AFFECTED SIB PAIR; DRUG-DEPENDENCE; SEMISTRUCTURED ASSESSMENT; SUBSTANCE DEPENDENCE; SUSCEPTIBILITY LOCI; NICOTINE DEPENDENCE; EUROPEAN-AMERICANS; CHRM2; GENE; MALE TWINS; ASSOCIATION;
D O I
10.1016/j.biopsych.2008.08.036
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: Alcohol dependence (AD) is costly to societies worldwide, moderately heritable, and genetically complex. Risk loci in several populations have been identified with genetic linkage analysis. To date, there has been no published linkage study of AD focused on African Americans (AAs). Methods: We completed a genomewide linkage scan with approximately 6000 single nucleotide polymorphism markers to map loci increasing risk for DSM-IV AD in a set of 238 small nuclear families ascertained on the basis of multiple individuals affected with cocaine or opioid dependence. Model free linkage analysis was completed with Merlin software. A modified marker set was used to avoid bias due to markers in strong linkage disequilibrium. Results: We identified a genomewide-significant linkage to markers near 117.2 centiMorgans on chromosome 10q23.3-24.1 (logarithm of odds score 3.32; p = 5.0E-05; empirical genomewide p = .033). Conclusions: These data add to the growing evidence for locations for AD risk loci and provide the first linkage evidence for such a locus in the AA population.
引用
收藏
页码:111 / 115
页数:5
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