A Fully Automated Radiosynthesis of [18F]Fluoroethyl-Diprenorphine on a Single Module by Use of SPE Cartridges for Preparation of High Quality 2-[18F]Fluoroethyl Tosylate

被引：20
|
作者：
Schoultz, Bent W. [1 ]
Reed, Brian J. [1 ,2 ]
Marton, Janos [3 ]
Willoch, Frode [2 ]
Henriksen, Gjermund [2 ,4 ]
机构：
[1] Univ Oslo, Dept Chem, N-0315 Oslo, Norway
[2] Univ Oslo, Inst Basic Med Sci, N-0317 Oslo, Norway
[3] ABX GmbH, D-01454 Radeberg, Germany
[4] Norwegian Med Cyclotron Ctr, N-0424 Oslo, Norway
来源：
MOLECULES | 2013年 / 18卷 / 06期
关键词：
2-[F-18]fluoroethyl tosylate; F-18-fluoroalkylation; PET; opioid receptors; automation; solid phase extraction;
D O I：
10.3390/molecules18067271
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We have developed a new method for automated production of 2-[F-18]fluoroethyl tosylate ([F-18]FETos) that enables F-18-alkylation to provide PET tracers with high chemical purity. The method is based on the removal of excess ethylene glycol bistosylate precursor by precipitation and subsequent filtration and purification of the filtrate by means of solid phase extraction cartridges (SPE). The method is integrated to a single synthesis module and thereby provides the advantage over previous methods of not requiring HPLC purification, as demonstrated by the full radiosynthesis of the potent opioid receptor PET tracer [F-18]fluoroethyldiprenorphine.
引用
收藏
页码：7271 / 7278
页数：8
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