Synthesis of α-[5-(5-amino-1,3,4-thiadiazol-2-yl)-2-imidazolylthio]acetic acids

被引：15
|
作者：
Hadizadeh, Farzin [1 ,2 ]
Vosooghi, Rahil [1 ]
机构：
[1] Mashhad Univ Med Sci, Fac Pharm, Dept Med Chem, Mashhad, Iran
[2] Mashhad Univ Med Sci, Biotechnol & Pharmaceut Res Ctr, Mashhad, Iran
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2008年 / 45卷 / 05期
关键词：
D O I：
10.1002/jhet.5570450537
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The paper describes synthesis and antituberculosis activity of alpha-[5-(5-amino-1,3,4-thiadiazol-2-yl)imidazol-2-ylthio] acetic acids (5a,b). The compounds were tested against Mycobacterium tuberculosis strain H37Rv in comparison to rifampicin. Compounds exhibited low activity (MIC >= 6.25 mu g/ml, % inhibition <= 24).
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页码：1477 / 1479
页数：3
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