Synthesis and Biological Activity of [5-(Arylmethylideneamino)-1,3,4-thiadiazol-2-yl]thioacetanilides

被引:0
|
作者
Wei, Tai-Bao [1 ]
Wang, Wen-Li [1 ]
Guo, Xiao-Di [1 ]
Xu, Rong [1 ]
Zhang, You-Ming [1 ]
Da, Wen-Yan [2 ]
机构
[1] NW Normal Univ, Coll Chem & Chem Engn, Gansu Key Lab Polymer Mat, Lanzhou 730070, Peoples R China
[2] NW Normal Univ, Coll Life Sci, Lanzhou 730070, Peoples R China
关键词
5-(arylmethylideneamino)-1,3,4-thiadiazol-2-yl]thioacetanilide; synthesis; bioactivity; phase transfer catalysis;
D O I
暂无
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Sixteen novel derivatives of [5-(arylmethylideneamino)-1,3,4-thiadiazol-2-yl]thioacetanilide were synthesized by the reaction of S-alkylation of 5-arylmethylideneamino-2-mercapto-1,3,4-thiadiazole with chloroacetanilides under the conditions of solid-liquid phase transfer catalysis using PEG-400 as a phase transfer catalyst in the presence of potassium carbonate. All the products were characterized by elemental analysis, FT-IR, H-1 NMR and C-13 NMR spectra. The preliminary biological activity tests showed that some of the title compounds had obvious regulating activities for the growth of wheat, and some compounds such as 4a and 4e possessed satisfactory activity of growth inhibition against B. subtilis at a test concentration (20 mg/mL).
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页码:1820 / 1825
页数:6
相关论文
共 21 条
  • [1] Synthesis and anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation activities of some new 2-[(2,6-dichloroanilino) phenyl]acetic acid derivatives
    Amir, M
    Shikha, K
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2004, 39 (06) : 535 - 545
  • [2] The influence of some new 2,5-disubstituted 1,3,4-thiadiazoles on the corrosion behaviour of mild steel in 1 M HCl solution:: AC impedance study and theoretical approach
    Bentiss, F.
    Lebrini, M.
    Lagrenee, M.
    Traisnel, M.
    Elfarouk, A.
    Vezin, H.
    [J]. ELECTROCHIMICA ACTA, 2007, 52 (24) : 6865 - 6872
  • [3] Chao SJ, 2005, ACTA CHIM SINICA, V63, P525
  • [4] Anticonvulsant activity of analogues of acetazolamide
    Chufán, EE
    Pedregosa, JC
    Baldini, ON
    Bruno-Blanch, L
    [J]. FARMACO, 1999, 54 (11-12): : 838 - 841
  • [5] Dong WL, 2007, CHEM J CHINESE U, V28, P1671
  • [6] Guru N, 2001, J SCI IND RES INDIA, V60, P601
  • [7] HOU XT, 2001, AGROCHEMICALS, V3, P19
  • [8] Jin GY, 1997, CHEM J CHINESE U, V18, P409
  • [9] JOANNA M, 2007, EUR J MED CHEM, V42, P940
  • [10] Li ML, 2007, INDIAN J CHEM B, V46, P544