MicroRNA single-nucleotide polymorphisms and diabetes mellitus: A comprehensive review

被引：27

作者：

Zhang, Yanfen ^{[1
]}

Bai, Ruocen ^{[1
]}

Liu, Chong ^{[2
]}

Ma, Chunyan ^{[1
]}

Chen, Xin ^{[1
]}

Yang, Jun ^{[1
]}

Sun, Dandan ^{[1
]}

机构：

[1] China Med Univ, Affiliated Hosp 1, Dept Cardiovasc Ultrasound, 155 North Nanjing St, Shenyang 110001, Liaoning, Peoples R China

[2] China Med Univ, Affiliated Hosp 1, Dept Intervent, Shenyang 110001, Liaoning, Peoples R China

来源：

CLINICAL GENETICS | 2019年 / 95卷 / 04期

基金：

中国国家自然科学基金;

关键词：

diabetes mellitus; diabetic complication; MicroRNA; single-nucleotide polymorphism; CIRCULATING MIRNA PROFILES; CARDIOVASCULAR-DISEASE; EXPRESSION PROFILES; BIOGENESIS PATHWAYS; SMALL RNAS; TYPE-2; ASSOCIATION; RISK; MIR-146A; SUSCEPTIBILITY;

D O I：

10.1111/cge.13491

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Diabetes mellitus (DM) has become the third major chronic non-communicable disease affecting global public health, following cancer and cardiovascular and cerebrovascular diseases. Although previous studies have found a correlation between microRNA (miRNA) and the development of DM, thus far, most reviews have focused on the studies describing the changes in miRNA expression profiles and the mechanisms by which miRNAs-induce DM. However, reviews summarizing the effect of miRNA single-nucleotide polymorphisms on the developmental stages of DM and its complications are still needed. Studies on the variation of miRNAs will not only help to further understand the role that genetic factors play in DM, but will also have important implications for treatment and disease prognosis.

引用

页码：451 / 461

页数：11

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